Lamivudine

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Lamivudine structure.jpg
lamivudine
IUPAC name: see chemistry section
Synonyms: 3TC, see Brand names
Formula: C8H11N3O3S

 Uses: HIV/AIDS & Hep. B

 Properties: cytosine-like RT inhibitor

 Hazards: see drug interactions

Mass (g/mol): CAS #:
229.2562 134678-17-4


Lamivudine is a nucleotide-based reverse transcriptase inhibitor used to treat HIV/AIDS and hepatitis B virus. It is an analog of zalcitabine that competes, in the triphosphate form, for incorporation in viral DNA with cytosine triphosphate. Lacking a 3'-OH group, it terminates DNA chain elongation because the phosphodiester bond necessary for elongation cannot be made.

Its IUPAC name is 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one and it has chemical formula C8H11N3O3S, giving it a molecular mass of 229.2562 g/mol.

Brand names

single drug brand names

  • 3TC
  • Epivir
  • Epivir-HBV
  • Hepitec
  • Heptovir
  • Zeffix

brand mixtures

  • Combivir (Lamivudine + Zidovudine)
  • Kivexa (Abacavir (Abacavir Sulfate) + Lamivudine)
  • Trizivir (Abacavir (Abacavir Sulfate) + Lamivudine + Zidovudine)


External links

The most up-to-date information about Lamivudine and other drugs can be found at the following sites.