Cidofovir

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Cidofovir, a nucleoside analog used to treat HIV.
cidofovir
IUPAC name: see chemistry section
Synonyms: CDV, HPMPC®, Vistide®
Formula: C8H14N3O6P

 Uses: antiviral drug

 Properties: cytosine analog

 Hazards: renal failure

Mass (g/mol): CAS #:
279.1870 113852-37-2



Cidofovir (CDV) is an antiviral drug used to treat herpes cytomegalovirus (CMV) retinitis associated with HIV/AIDS. It is an analog of the natural nucleoside cytosine used in DNA. It selectively inhibits the CMV DNA polymerase, probably as the diphosphate, at concentrations 8- to 600-fold lower than needed to inhibit human DNA polymerases. Once incorporated into the growing viral DNA chain, the rate of DNA chain synthesis is reduced. Kidney damage and reduced levels of white blood cells and platelets may occur when using this drug. Warning:Acute renal failure requiring dialysis and/or contributing to death have occurred with as few as one or two doses of cidofovir.

Chemistry

Its chemical name is [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid and its chemical formula is C8H14N3O6P. It is sold under the brand names HPMPC and Vistide.


External Links

The most up-to-date information about Cidofovir and other drugs can be found at the following sites.