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Talk:Evolution of appetite regulating systems

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Revision as of 11:52, 23 November 2010 by Gareth Leng (Talk | contribs) (Feedback)

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 Definition Comparisons of the mechanisms regulating food intake and energy expenditure between species. [d] [e]
  1. Manik Kohli 13:16, 28 September 2010 (UTC)
  2. Sophie A. Clarke 13:19, 28 September 2010 (UTC)


Manik and Sophie, I cut and pasted your reference list into the Bibliography page, remember to use that page rather than the Talk page for references. Sophie, You don't have to sign after each entry, you can enter several ref then sign at the end of your list. It's a nice selection, good start. Nancy Sabatier 17:00, 5 October 2010 (UTC)

Sophie, Manik, the article looks good so far! I think it was a good idea to select one of the most important genes in the control of food intake rather than trying to write about npy, leptin, ghrelin and all the other, seemingly endless, gene products that are involved. The article outline is good, how is the fleshing-out coming on? John Menzies 11:20, 27 October 2010 (UTC)

Related articles

You'll see that on the Related articles subpage I've placed links to all the articles from the other groups this year - and also to last year's articles. Good luck with this.Gareth Leng 15:58, 9 October 2010 (UTC)

Good bibliography - I'm really looking forward to seeing this article!Gareth Leng 14:07, 16 October 2010 (UTC)

Good work Sophie. Manik, looking forward to seeing your contribution to the writing of the Main Article. Nancy Sabatier 12:58, 8 November 2010 (UTC)

What do we know of the distribution and functions of POMC through evolution - where did its role in appetite come from? Cqan we learn anything about the role of POMC in mammals from its role and physiology in invertebrates?Gareth Leng 17:36, 13 November 2010 (UTC)

Feedback

Some very impressive work on this article. Some specific minor concerns

"Ghrelin was shown using fluorescent protein tagged NPY neurons, to increase release of NPY and AgRP" No, need to check on exactly what was done.

"It is thought that the NPY/AgRP neurons project to inhibit the POMC neurons, partly mediated through GABA" I've added 'partly' here - NPY is also inhibitory to these neurons, but you're right in that the main direct effect is via GABA.

"There are five NPY receptors (Y1-Y5), which are also activated by the closely related peptide PYY." I cut the second half of the sentence as I think PYY is predominantly active at the Y2 receptor

Overall - this is an excellent effort. The evolution of these systems is very interesting in itself, but the practical importance of the high degree of conservation through evolution is that we can learn a lot about the role of POMC regulation of human appetite from studies in other animals.

Gareth Leng 11:38, 23 November 2010 (UTC)