Ovarian cancer: Difference between revisions
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== | ==Diagnosis== | ||
=== | ===Symptoms=== | ||
Two [[case-control]] studies, both subject to results being inflated by [[spectrum bias]],have been reported. The first found that women with ovarian cancer had symptoms of increased abdominal size, bloating, urinary urgency, and pelvic pain.<ref name="pmid15187051">{{cite journal |author=Goff BA, Mandel LS, Melancon CH, Muntz HG |title=Frequency of symptoms of ovarian cancer in women presenting to primary care clinics |journal=JAMA |volume=291 |issue=22 |pages=2705-12 |year=2004 |pmid=15187051 |doi=10.1001/jama.291.22.2705}}PMID 15187051</ref> The smaller, second study found that women with ovarian cancer had pelvic/abdominal pain, increased abdominal size/bloating, and difficulty eating/feeling full.<ref name="pmid17154394">{{cite journal |author=Goff BA, Mandel LS, Drescher CW, ''et al'' |title=Development of an ovarian cancer symptom index: possibilities for earlier detection |journal=Cancer |volume=109 |issue=2 |pages=221-7 |year=2007 |pmid=17154394 |doi=10.1002/cncr.22371}}PMID 17154394 </ref> The latter study created a symptom index that was considered positive if any of the 6 symptoms "occurred >12 times per month but were present for <1 year".They reported a [[sensitivity (tests)|sensitivity]] of 57% for early-stage disease and [[specificity (tests)|specificity]] 87% to 90%. In a large validation of the symptom index, the sensitivies were never over 70% whie the specificities were over 90%.<ref>{{Cite journal | Two [[case-control]] studies, both subject to results being inflated by [[spectrum bias]],have been reported. The first found that women with ovarian cancer had symptoms of increased abdominal size, bloating, urinary urgency, and pelvic pain.<ref name="pmid15187051">{{cite journal |author=Goff BA, Mandel LS, Melancon CH, Muntz HG |title=Frequency of symptoms of ovarian cancer in women presenting to primary care clinics |journal=JAMA |volume=291 |issue=22 |pages=2705-12 |year=2004 |pmid=15187051 |doi=10.1001/jama.291.22.2705}}PMID 15187051</ref> The smaller, second study found that women with ovarian cancer had pelvic/abdominal pain, increased abdominal size/bloating, and difficulty eating/feeling full.<ref name="pmid17154394">{{cite journal |author=Goff BA, Mandel LS, Drescher CW, ''et al'' |title=Development of an ovarian cancer symptom index: possibilities for earlier detection |journal=Cancer |volume=109 |issue=2 |pages=221-7 |year=2007 |pmid=17154394 |doi=10.1002/cncr.22371}}PMID 17154394 </ref> The latter study created a symptom index that was considered positive if any of the 6 symptoms "occurred >12 times per month but were present for <1 year".They reported a [[sensitivity (tests)|sensitivity]] of 57% for early-stage disease and [[specificity (tests)|specificity]] 87% to 90%. In a large validation of the symptom index, the sensitivies were never over 70% whie the specificities were over 90%.<ref>{{Cite journal | ||
| doi = 10.1093/jnci/djp500 | | doi = 10.1093/jnci/djp500 | ||
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| url = http://jnci.oxfordjournals.org/cgi/content/abstract/jnci;djp500v1 | | url = http://jnci.oxfordjournals.org/cgi/content/abstract/jnci;djp500v1 | ||
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==Screening== | |||
Screen with annual [[CA-125 antigen]] and transvaginal [[ultrasonography]] does not reduce mortality according to the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.<ref name="pmid21642681">{{cite journal| author=Buys SS, Partridge E, Black A, Johnson CC, Lamerato L, Isaacs C et al.| title=Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. | journal=JAMA | year= 2011 | volume= 305 | issue= 22 | pages= 2295-303 | pmid=21642681 | doi=10.1001/jama.2011.766 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21642681 }} </ref> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 08:53, 13 June 2011
Diagnosis
Symptoms
Two case-control studies, both subject to results being inflated by spectrum bias,have been reported. The first found that women with ovarian cancer had symptoms of increased abdominal size, bloating, urinary urgency, and pelvic pain.[1] The smaller, second study found that women with ovarian cancer had pelvic/abdominal pain, increased abdominal size/bloating, and difficulty eating/feeling full.[2] The latter study created a symptom index that was considered positive if any of the 6 symptoms "occurred >12 times per month but were present for <1 year".They reported a sensitivity of 57% for early-stage disease and specificity 87% to 90%. In a large validation of the symptom index, the sensitivies were never over 70% whie the specificities were over 90%.[3]
Screening
Screen with annual CA-125 antigen and transvaginal ultrasonography does not reduce mortality according to the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.[4]
References
- ↑ Goff BA, Mandel LS, Melancon CH, Muntz HG (2004). "Frequency of symptoms of ovarian cancer in women presenting to primary care clinics". JAMA 291 (22): 2705-12. DOI:10.1001/jama.291.22.2705. PMID 15187051. Research Blogging. PMID 15187051
- ↑ Goff BA, Mandel LS, Drescher CW, et al (2007). "Development of an ovarian cancer symptom index: possibilities for earlier detection". Cancer 109 (2): 221-7. DOI:10.1002/cncr.22371. PMID 17154394. Research Blogging. PMID 17154394
- ↑ Rossing, Mary Anne; Kristine G. Wicklund, Kara L. Cushing-Haugen, Noel S. Weiss (2010-01-28). "Predictive Value of Symptoms for Early Detection of Ovarian Cancer". J. Natl. Cancer Inst.: djp500. DOI:10.1093/jnci/djp500. Retrieved on 2010-01-29. Research Blogging.
- ↑ Buys SS, Partridge E, Black A, Johnson CC, Lamerato L, Isaacs C et al. (2011). "Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial.". JAMA 305 (22): 2295-303. DOI:10.1001/jama.2011.766. PMID 21642681. Research Blogging.