New Delhi metallo-beta-lactamase-1: Difference between revisions
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| url = http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1198-743X&date=2002&volume=8&issue=6&spage=321}}</ref> These organisms often are also resistant to [[quinolone|fluoroquinolone]]s and [[aminoglycoside]]s. | | url = http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1198-743X&date=2002&volume=8&issue=6&spage=321}}</ref> These organisms often are also resistant to [[quinolone|fluoroquinolone]]s and [[aminoglycoside]]s. | ||
First reported in ''[[Klebsiella pneumoniae]]'', it has been reported in ''[[Acinetobacter | First reported in ''[[Klebsiella pneumoniae]]'', it has been reported in ''[[Acinetobacter]], [[Escherichia coli]], [[Citrobacter freundii]], [[Enterobacter cloacae]]'', and ''[[Morganella morganii]]''. A number of cases have been found in Britain, Canada and the US in patients that went to India for medical procedures or were treated for emergencies while in India.<ref>{{citation | ||
| title = NDM-1 carrying Enterobacteriaceae - worldwide ex India, Pakistan (02) | | title = NDM-1 carrying Enterobacteriaceae - worldwide ex India, Pakistan (02) | ||
| journal = ProMED Emerging Disease Report, International Society for Infectious Diseases | | journal = ProMED Emerging Disease Report, International Society for Infectious Diseases | ||
Revision as of 17:35, 14 September 2010
New Delhi metallo-beta-lactamase-1 enzyme confers bacterial resistance to antibiotics of the carbepenem class, often considered "last resort" drugs for multidrug resistant bacteria.[1] The gene to manufacture it can be horizontally transferred among different species of pathogenic bacteria.
Organisms that produce the enzyme are resistant to virtually all beta-lactam antibiotics except azneotram. [2] These organisms often are also resistant to fluoroquinolones and aminoglycosides.
First reported in Klebsiella pneumoniae, it has been reported in Acinetobacter, Escherichia coli, Citrobacter freundii, Enterobacter cloacae, and Morganella morganii. A number of cases have been found in Britain, Canada and the US in patients that went to India for medical procedures or were treated for emergencies while in India.[3]
References
- ↑ Krishna B (2010 [cited 2010 Sep 14]), "New Delhi metallo-beta-lactamases: A wake-up call for microbiologists", Indian J Med Microbiol [serial online] 28: 265-6.
- ↑ >Nordmann P, Poirel L. (2002), "Emerging carbapenemases in Gram-negative aerobes", Clin Microbiol Infect 8: 321-31
- ↑ "NDM-1 carrying Enterobacteriaceae - worldwide ex India, Pakistan (02)", ProMED Emerging Disease Report, International Society for Infectious Diseases, 14 September 2010