File:RNAsilenceOVERVIEW.jpg: Revision history

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11 March 2022

16 December 2006

  • curprev 18:4518:45, 16 December 2006‎ imported>David Tribe‎ 1,776 bytes +1,776‎ Short RNAs derived from Dicer cleavage of dsRNA are incorporated into multiprotein effector complexes, such as RISC and RITS (RNA-induced initiation of TGS) (Verdel et al. 2004) to target mRNA degradation (RNAi/PTGS), translation inhibition, or TGS and genome modifications. ARGONAUTE (AGO) proteins (the name comes from a plant mutant [Bohmert et al. 1998]) bind short RNAs and ‘shepherd’ them to appropriate effector complexes (Carmell et al. 2002). siRNAs originate from perfect RNA duplexes, w...
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