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== '''[[Acute coronary syndrome]]''' ==
== '''[[Human rights]]''' ==
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In [[medicine]] and [[cardiology]], '''acute coronary syndrome''' (ACS) is a collection of [[sign (medical)|signs]] and [[symptom]]s due to inadequate oxygenation of the heart muscle, the [[myocardium]], usually due to [[coronary artery disease]].<ref>{{MeSH}}</ref> ACS includes [[myocardial infarction]] ("heart attack") and  [[angina]].


Pain relief and proper oxygenation is the core of ACS treatment. When the root causie is angina, the temporary cause of ischemia should be reversed. For myocardial infarction, more vigorous interventions are appropriate if they can prevent damage to myocardium.
The concept of '''human rights''' as the innate entitlement of all human beings found early expression during  the American and French revolutionary movements of the late 18th century,  but received  little further development until the conclusion of World War II. It then  acquired the current connotation of a body of entitlements whose realisation  is considered to be a universal obligation. This article is about the implementation of that concept of human rights. Doubts have been expressed about its ethical foundations, and about its philosophical consistency, but its emotional impact upon worldwide consciousness is beyond doubt. As a result, it has acquired considerable political importance, and  has been embodied in a wide range of generally-accepted international  treaty obligations. There have been numerous breaches of those undertakings, and there is widespread disagreement concerning the appropriate international response to such  breaches.


===Etiology/causes===
===The nature of the concept===
====Atheroclerotic obstruction====
As an ethical concept, the term  human rights is not susceptible to precise definition concerning either its content or its scope. The generally-held  judgement that torture is wrong does not depend upon agreement concerning the degree of pain or discomfort that it involves; and the ethical purpose of banning it is served if the ban puts an end to what most people consider to be torture. There is widespread agreement  concerning many of the practices that are considered to be breaches of human rights, but the disagreements that exist -  concerning, for example, abortion, the death penalty and blasphemy - are  not held to justify  a wholesale rejection of the concept. And, although human rights are generally considered to be innate to their possessors, the fact  they can be given effect only by the assent of others, makes them difficult to distinguish from community-granted rights.
ACS is usually caused by obstruction in an epicardial coronary artery.<ref name="pmid18687244">{{cite journal |author=Ong P, Athanasiadis A, Hill S, Vogelsberg H, Voehringer M, Sechtem U |title=Coronary artery spasm as a frequent cause of acute coronary syndrome: The CASPAR (Coronary Artery Spasm in Patients With Acute Coronary Syndrome) Study |journal=J. Am. Coll. Cardiol. |volume=52 |issue=7 |pages=523–7 |year=2008 |month=August |pmid=18687244 |doi=10.1016/j.jacc.2008.04.050 |url=http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(08)01872-X |issn=}}</ref> The obstruction may be due to a thrombus at the site of a ruptured atherosclerotic plaque.<ref name="pmid1728732">{{cite journal |author=Mizuno K, Satomura K, Miyamoto A, ''et al'' |title=Angioscopic evaluation of coronary-artery thrombi in acute coronary syndromes |journal=N. Engl. J. Med. |volume=326 |issue=5 |pages=287–91 |year=1992 |month=January |pmid=1728732 |doi= |url= |issn=}}</ref>


Rupture seems more likely to occur during the morning hours.<ref name="pmid2865677">{{cite journal |author=Muller JE, Stone PH, Turi ZG, ''et al'' |title=Circadian variation in the frequency of onset of acute myocardial infarction |journal=N. Engl. J. Med. |volume=313 |issue=21 |pages=1315–22 |year=1985 |month=November |pmid=2865677 |doi= |url= |issn=}}</ref> Rupture may be precipited by inflammation from non-cardiac infections.<ref name="pmid18293142">{{cite journal |author=Harskamp RE, van Ginkel MW |title=Acute respiratory tract infections: a potential trigger for the acute coronary syndrome |journal=Ann. Med. |volume=40 |issue=2 |pages=121–8 |year=2008 |pmid=18293142 |doi=10.1080/07853890701753672 |url=http://www.informaworld.com/openurl?genre=article&doi=10.1080/07853890701753672&magic=pubmed&#124;&#124;1B69BA326FFE69C3F0A8F227DF8201D0 |issn=}}</ref> Rupture may be triggered by vigorous exercise among individuals who do not ordinarily do vigorous exercise.<ref name="pmid6472399">{{cite journal |author=Siscovick DS, Weiss NS, Fletcher RH, Lasky T |title=The incidence of primary cardiac arrest during vigorous exercise |journal=N. Engl. J. Med. |volume=311 |issue=14 |pages=874–7 |year=1984 |month=October |pmid=6472399 |doi= |url= |issn=}}</ref>
===The historical background===
 
The  1948 [[/Addendum#The Universal Declaration of Human Rights (1948)|Universal Declaration of Human Rights]] is generally held to have been inspired by revulsion at the treatment or the victims of the [[holocaust]] and by  wartime aspirations for a better post-war world. Although much of its  content was  new, there were precedents for its concept of  universally innate human entitlements in the [[/Addendum#TheAmerican Declaration of Independence|American Declaration of Independence]] and the [[/Addendum#The French Declaration of the Rights of Man|French Declaration of the Rights of Man]]. Its unprecedented feature was its claim to be doubly universal - to invoke the universal acceptance of agreed obligations, as well as the recognition of what were agreed to be universal entitlements. It was an overstated claim, however, in view of the absence among it signatories of many of the  countries that are now members of the United Nations, and the fact that many of its signatories  were themselves in breach of its proposed obligations<ref>[http://tannerlectures.utah.edu/lectures/documents/Ignatieff_01.pdf  Ignatieff, Michael: '' Human Rights as Politics'' and '' Human Rights as Idolatry'']  (lectures delivered at Princeton University April 4–7, 2000)</ref>. The actual content of the declaration was, as Justice Michael Kirby recalls
====Coronary vasospasm====
<ref>[http://www.lawfoundation.net.au/ljf/app/&id=1A826DB973993289CA2571A700012832 Michael Kirby: ''The Universal Declaration of Human Rights - Fifty Years On''] (Speech at an UNESCO dinner at Sydney on 5 December 1998)</ref> a political compromise, and rights were included that apparently stood little chance of unqualified implementation.
Approximately 15% of NSTEMI and 2% of STEMI patients have no obstruction of coronary vessels and in about half of these patients, spasm can be induced of a coronary artery.<ref name="pmid18687244"/>


''[[Acute coronary syndrome|.... (read more)]]''
''[[Acute coronary syndrome|.... (read more)]]''
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Revision as of 10:00, 15 September 2012

Human rights


The concept of human rights as the innate entitlement of all human beings found early expression during the American and French revolutionary movements of the late 18th century, but received little further development until the conclusion of World War II. It then acquired the current connotation of a body of entitlements whose realisation is considered to be a universal obligation. This article is about the implementation of that concept of human rights. Doubts have been expressed about its ethical foundations, and about its philosophical consistency, but its emotional impact upon worldwide consciousness is beyond doubt. As a result, it has acquired considerable political importance, and has been embodied in a wide range of generally-accepted international treaty obligations. There have been numerous breaches of those undertakings, and there is widespread disagreement concerning the appropriate international response to such breaches.

The nature of the concept

As an ethical concept, the term human rights is not susceptible to precise definition concerning either its content or its scope. The generally-held judgement that torture is wrong does not depend upon agreement concerning the degree of pain or discomfort that it involves; and the ethical purpose of banning it is served if the ban puts an end to what most people consider to be torture. There is widespread agreement concerning many of the practices that are considered to be breaches of human rights, but the disagreements that exist - concerning, for example, abortion, the death penalty and blasphemy - are not held to justify a wholesale rejection of the concept. And, although human rights are generally considered to be innate to their possessors, the fact they can be given effect only by the assent of others, makes them difficult to distinguish from community-granted rights.

The historical background

The 1948 Universal Declaration of Human Rights is generally held to have been inspired by revulsion at the treatment or the victims of the holocaust and by wartime aspirations for a better post-war world. Although much of its content was new, there were precedents for its concept of universally innate human entitlements in the American Declaration of Independence and the French Declaration of the Rights of Man. Its unprecedented feature was its claim to be doubly universal - to invoke the universal acceptance of agreed obligations, as well as the recognition of what were agreed to be universal entitlements. It was an overstated claim, however, in view of the absence among it signatories of many of the countries that are now members of the United Nations, and the fact that many of its signatories were themselves in breach of its proposed obligations[1]. The actual content of the declaration was, as Justice Michael Kirby recalls [2] a political compromise, and rights were included that apparently stood little chance of unqualified implementation.

.... (read more)