CZ:Featured article/Current: Difference between revisions

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(→‎Hypercholesterolemia: Mission San José)
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== '''[[Hypercholesterolemia]]''' ==
== '''[[Mission San José]]''' ==
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'''Hypercholesterolemia''' is "a condition with abnormally high levels of [[cholesterol]] in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population."<ref name="title">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?term=Hypercholesterolemia |title=Hypercholesterolemia |accessdate=2008-01-18 |author=Anonymous |authorlink= |coauthors= |date= |format= |work= |publisher=National Library of Medicine }}</ref> It should be differentiated from [[dyslipidemia]], where the total cholesterol may not be abnormally high, but the ratios of lipid components are in an unhealthy range.


===Prognostication===
Non-HDL cholesterol and [[apolipoprotein]] B levels may better predict subsequent [[vascular disease]] thatn LDL-C levels.<ref name="pmid22453571">{{cite journal| author=Boekholdt SM, Arsenault BJ, Mora S, Pedersen TR, LaRosa JC, Nestel PJ et al.| title=Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. | journal=JAMA | year= 2012 | volume= 307 | issue= 12 | pages= 1302-9 | pmid=22453571 | doi=10.1001/jama.2012.366 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22453571  }} </ref>According to the Friedewald formula, non-HDL cholesterol is LDL-cholesterol LDL-C and VLDL-C.<ref name="pmid4337382">{{cite journal| author=Friedewald WT, Levy RI, Fredrickson DS| title=Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | journal=Clin Chem | year= 1972 | volume= 18 | issue= 6 | pages= 499-502 | pmid=4337382 | doi= | pmc= | url= }} </ref> If LDL-C levels are used as goals of therapy:<ref name="pmid12485966">{{cite journal| author=National  Cholesterol Education Program (NCEP) Expert Panel on Detection,  Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult  Treatment Panel III)|  title=Third Report of the National Cholesterol Education Program (NCEP)  Expert Panel on Detection, Evaluation, and Treatment of High Blood  Cholesterol in Adults (Adult Treatment Panel III) final report. | journal=Circulation | year= 2002 | volume= 106 | issue= 25 | pages= 3143-421 | pmid=12485966 | doi= | pmc= | url= }} </ref>


'''Mission San José''' was founded on Trinity Sunday (June 11), 1797 on a site located in the "Mission San Jose District" of Fremont, California (formerly an independent town, a spot that the natives called ''Oroysom'' or ''Orisom'') in the "Valley of San José."  The settlement was the site of the first Ceasarian section childbirth in Alta California.<ref name="ruscin196">Ruscin, p. 196</ref> The Mission entered a long period of gradual decline after secularization in 1834, though numerous restoration efforts in the intervening periods have reconstructed many of the original structures. The original padre's quarters are now a small museum; Saint Joseph's Church at the Mission San José is today a local parish church of the Roman Catholic Diocese of Oakland.


''[[Hypercholesterolemia|.... (read more)]]''
In the early part of the 1900s a sign was erected on the roof of the museum which read "Mission San Jose de Guadalupe" (in reference to ''el pueblo de San José de Guadalupe'', the first civic settlement in Alta California, founded in 1777&nbsp;<ref name="ruscin196">Ruscin, p. 196</ref>). This misnomer is often used by authors and even government agencies to this day when referring to the installation.
 
 
''[[Mission San José|.... (read more)]]''


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Revision as of 04:58, 19 January 2013

Mission San José


Mission San José was founded on Trinity Sunday (June 11), 1797 on a site located in the "Mission San Jose District" of Fremont, California (formerly an independent town, a spot that the natives called Oroysom or Orisom) in the "Valley of San José." The settlement was the site of the first Ceasarian section childbirth in Alta California.[1] The Mission entered a long period of gradual decline after secularization in 1834, though numerous restoration efforts in the intervening periods have reconstructed many of the original structures. The original padre's quarters are now a small museum; Saint Joseph's Church at the Mission San José is today a local parish church of the Roman Catholic Diocese of Oakland.

In the early part of the 1900s a sign was erected on the roof of the museum which read "Mission San Jose de Guadalupe" (in reference to el pueblo de San José de Guadalupe, the first civic settlement in Alta California, founded in 1777 [1]). This misnomer is often used by authors and even government agencies to this day when referring to the installation.


.... (read more)

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