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== '''[[Hypercholesterolemia]]''' ==
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'''Hypercholesterolemia''' is "a condition with abnormally high levels of [[cholesterol]] in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population."<ref name="title">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?term=Hypercholesterolemia |title=Hypercholesterolemia |accessdate=2008-01-18 |author=Anonymous |authorlink= |coauthors= |date= |format= |work= |publisher=National Library of Medicine }}</ref> It should be differentiated from [[dyslipidemia]], where the total cholesterol may not be abnormally high, but the ratios of lipid components are in an unhealthy range.
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===Prognostication===
Non-HDL cholesterol and [[apolipoprotein]] B levels may better predict subsequent [[vascular disease]] thatn LDL-C levels.<ref name="pmid22453571">{{cite journal| author=Boekholdt SM, Arsenault BJ, Mora S, Pedersen TR, LaRosa JC, Nestel PJ et al.| title=Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. | journal=JAMA | year= 2012 | volume= 307 | issue= 12 | pages= 1302-9 | pmid=22453571 | doi=10.1001/jama.2012.366 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22453571  }} </ref>According to the Friedewald formula, non-HDL cholesterol is LDL-cholesterol LDL-C and VLDL-C.<ref name="pmid4337382">{{cite journal| author=Friedewald WT, Levy RI, Fredrickson DS| title=Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | journal=Clin Chem | year= 1972 | volume= 18 | issue= 6 | pages= 499-502 | pmid=4337382 | doi= | pmc= | url= }} </ref> If LDL-C levels are used as goals of therapy:<ref name="pmid12485966">{{cite journal| author=National  Cholesterol Education Program (NCEP) Expert Panel on Detection,  Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult  Treatment Panel III)|  title=Third Report of the National Cholesterol Education Program (NCEP)  Expert Panel on Detection, Evaluation, and Treatment of High Blood  Cholesterol in Adults (Adult Treatment Panel III) final report. | journal=Circulation | year= 2002 | volume= 106 | issue= 25 | pages= 3143-421 | pmid=12485966 | doi= | pmc= | url= }} </ref>
 
 
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Latest revision as of 10:19, 11 September 2020

Napoleon (Napoleon Bonaparte or, after 1804, Napoleon I, Emperor of the French) was a world historic figure and dictator of France from 1799 to 1814. He was the greatest general of his age--perhaps any age, with a sure command of battlefield tactics and campaign strategies, As a civil leader he played a major role in the French Revolution, then ended it when he became dictator in 1799 and Emperor of France in 1804 He modernized the French military, fiscal, political legal and religious systems. He fought an unending series of wars against Britain with a complex, ever-changing coalition of European nations on both sides. Refusing to compromise after his immense defeat in Russia in 1812, he was overwhelmed by a coalition of enemies and abdicated in 1814. In 1815 he returned from exile, took control of France, built a new army, and in 100 days almost succeeded--but was defeated at Waterloo and exiled to a remote island. His image and memory are central to French national identity, but he is despised by the British and Russians and is a controversial figure in Germany and elsewhere in Europe.

The Trail of Napoleon - J.F. Horrabin - Map.jpg

Rise to Power

Once the Revolution had begun, so many of the aristocratic officers turned against the Revolutionary government, or were exiled or executed, that a vacuum of senior leadership resulted. Promotions came very quickly now, and loyalty to the Revolution was as important as technical skill; Napoleon had both. His demerits were overlooked as he was twice reinstated, promoted, and allowed to collect his back pay. Paris knew him as an intellectual soldier deeply involved in politics. His first test of military genius came at Toulon in 1793, where the British had seized this key port. Napoleon, an acting Lieutenant-Colonel, used his artillery to force the British to abandon the city. He was immediately promoted by the Jacobin radicals under Robespierre to brigadier-general, joining the ranks of several brilliant young generals. He played a major role in defending Paris itself from counter-revolutionaries, and became the operational planner for the Army of Italy and planned two successful attacks in April 1794. He married Josephine (Rose de Beauharnais) in 1796, after falling violently in love with the older aristocratic widow.[1]

Footnotes

  1. Englund pp 63-73, 91-2, 97-8