CD63 antigen: Difference between revisions
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In [[allergy and immunology]], the CD63 antigen is a [[glycoprotein]] with a molecular mass | |||
of 30-60 kDa,<ref>{{citation | |||
| title = CD63 Antigen: A Novel Lysosomal Membrane Glycoprotein, Cloned by a Screening Procedure for Intracellular Antigens in Eukaryotic Cells | |||
| author=Marcel J. Metzelaar ''et al.'' | |||
| volume = 266 | issue = 5 | date = 15 February 1991 | pages = 3239-3245 | |||
| url = http://www.jbc.org/content/266/5/3239.full.pdf | |||
}}</ref> which is activated by allergic sensitization of [[basophil]]s. Since basophils themselves are rare, it has proven convenient to measure their activation using [[flow cytometry]] of CD63. <ref>{{citation | |||
| journal = Clin Exp Immunol| date = March 1999|volume=115|issue =3| pages = 393-6 | |||
| title = Detection of allergen-induced basophil activation by expression of CD63 antigen using a tricolour flow cytometric method. | |||
| author = Monneret G, Gutowski MC, Bienvenu J. | |||
| url = http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9104&date=1999&volume=115&issue=3&spage=393}}</ref> | |||
==References== | |||
{{reflist}} | |||
Latest revision as of 16:43, 14 January 2011
In allergy and immunology, the CD63 antigen is a glycoprotein with a molecular mass of 30-60 kDa,[1] which is activated by allergic sensitization of basophils. Since basophils themselves are rare, it has proven convenient to measure their activation using flow cytometry of CD63. [2]
References
- ↑ Marcel J. Metzelaar et al. (15 February 1991), CD63 Antigen: A Novel Lysosomal Membrane Glycoprotein, Cloned by a Screening Procedure for Intracellular Antigens in Eukaryotic Cells, vol. 266, at 3239-3245
- ↑ Monneret G, Gutowski MC, Bienvenu J. (March 1999), "Detection of allergen-induced basophil activation by expression of CD63 antigen using a tricolour flow cytometric method.", Clin Exp Immunol 115 (3): 393-6