Naranjo algorithm

From Citizendium
Jump to navigation Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
This article is developing and not approved.
 Main Article
 Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
https://en.citizendium.org/wiki/index.php?title=Naranjo_algorithm&printable=yes
This editable Main Article is under development and subject to a disclaimer.

The Naranjo algorithm is a questionnaire designed by Naranjo et al[1] for determining the likelihood of whether an ADR (drug-related side effects and adverse reactions) is actually due to the medication rather than the result of other factors. Probability is assigned via a score termed definite, probable, possible or doubtful.

An alternative, simpler scale has been proposed by the World Health Organization (WHO).[2][3]

Questionnaire

1. Are there previous conclusive reports on this reaction?

Yes (+1) No (0) Do not know or not done (0)

2. Did the adverse event appear after the suspected drug was given?

Yes (+2) No (-1) Do not know or not done (0)

3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given?

Yes (+1) No (0) Do not know or not done (0)

4. Did the adverse reaction appear when the drug was readministered?

Yes (+2) No (-1) Do not know or not done (0)

5. Are there alternative causes that could have caused the reaction?

Yes (-1) No (+2) Do not know or not done (0)

6. Did the reaction reappear when a placebo was given?

Yes (-1) No (+1) Do not know or not done (0)

7. Was the drug detected in any body fluid in toxic concentrations?

Yes (+1) No (0) Do not know or not done (0)

8. Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?

Yes (+1) No (0) Do not know or not done (0)

9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?

Yes (+1) No (0) Do not know or not done (0)

Scoring

  • > 9 = definite ADR
  • 5-8 = probable ADR
  • 1-4 = possible ADR
  • 0 = doubtful ADR

References

  1. ↑ Naranjo CA, Busto U, Sellers EM, et al (1981). "A method for estimating the probability of drug-related side effects and adverse reactionss". Clin. Pharmacol. Ther. 30 (2): 239-45. PMID 7249508. [e]
  2. ↑ Edwards IR, Aronson JK (2000). "Drug-related side effects and adverse reactionss: definitions, diagnosis, and management". Lancet 356 (9237): 1255–9. DOI:10.1016/S0140-6736(00)02799-9. PMID 11072960. Research Blogging.
  3. ↑ Nebeker JR, Barach P, Samore MH (2004). "Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting". Ann. Intern. Med. 140 (10): 795–801. PMID 15148066. [e] (See table 2)

External links

Retrieved from "https://citizendium.org/wiki/index.php?title=Naranjo_algorithm&oldid=916929"