Fenofibrate: Difference between revisions
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[[Image:Fenofibrate structure.jpg|right|thumb|200px|{{#ifexist:Template:Fenofibrate structure.jpg/credit|{{Fenofibrate structure.jpg/credit}}<br/>|}}Fenofibrate.]] | [[Image:Fenofibrate structure.jpg|right|thumb|200px|{{#ifexist:Template:Fenofibrate structure.jpg/credit|{{Fenofibrate structure.jpg/credit}}<br/>|}}Fenofibrate.]] | ||
'''Fenofibrate''', also known as fenofibrato(Spanish), fenofibratum (Latin), FNF and finofibrate, is an antilipemic | '''Fenofibrate''', also known as fenofibrato(Spanish), fenofibratum (Latin), FNF and finofibrate, is an [[antilipemic agent]] which reduces both [[cholesterol]] and [[triglyceride]]s in the blood. Its IUPAC name is propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate and its chemical formula is C<sub>20</sub>H<sub>21</sub>ClO<sub>4</sub>. [[Fenofibric acid]] is the active metabolite of fenofibrate, that produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII. | ||
Fenofibrate also lowers [[uric acid]] in the blood.<ref name="pmid12595630">{{cite journal |author=Feher MD, Hepburn AL, Hogarth MB, Ball SG, Kaye SA |title=Fenofibrate enhances urate reduction in men treated with allopurinol for hyperuricaemia and gout |journal=Rheumatology (Oxford) |volume=42 |issue=2 |pages=321–5 |year=2003 |month=February |pmid=12595630 |doi= |url= |issn=}}</ref> | |||
Fenofibrate activates peroxisome proliferator activated receptor a (PPARa), which increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III. The resulting decrease in triglycerides alters the size and composition of LDL from small, dense particles, to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. | Fenofibrate activates peroxisome proliferator activated receptor a (PPARa), which increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III. The resulting decrease in triglycerides alters the size and composition of LDL from small, dense particles, to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. | ||
== Brand Names == | == Brand Names == | ||
<div class= style="-moz-column-count:3; column-count:3;"> | |||
*Ankebin | *Ankebin | ||
*Antara | *Antara | ||
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*Tricor | *Tricor | ||
*Triglide | *Triglide | ||
</div> | |||
==External Links == | ==External Links == | ||
{{CZMed} | |||
Revision as of 23:00, 21 February 2009
Fenofibrate, also known as fenofibrato(Spanish), fenofibratum (Latin), FNF and finofibrate, is an antilipemic agent which reduces both cholesterol and triglycerides in the blood. Its IUPAC name is propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate and its chemical formula is C20H21ClO4. Fenofibric acid is the active metabolite of fenofibrate, that produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Fenofibrate also lowers uric acid in the blood.[1]
Fenofibrate activates peroxisome proliferator activated receptor a (PPARa), which increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III. The resulting decrease in triglycerides alters the size and composition of LDL from small, dense particles, to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly.
Brand Names
- Ankebin
- Antara
- Elasterate
- Elasterin
- Fenobrate
- Fenogal
- Fenotard
- Lipanthyl
- Lipantil
- Lipidex
- Lipidil
- Lipidil Micro
- Lipidil Supra
- Lipifen
- Lipirex
- Lipoclar
- Lipofene
- Liposit
- Lipsin
- Lofibra
- Luxacor
- Nolipax
- Procetofen
- Proctofene
- Protolipan
- Secalip
- Sedufen
- Tricor
- Triglide
External Links
{{CZMed}
- ↑ Feher MD, Hepburn AL, Hogarth MB, Ball SG, Kaye SA (February 2003). "Fenofibrate enhances urate reduction in men treated with allopurinol for hyperuricaemia and gout". Rheumatology (Oxford) 42 (2): 321–5. PMID 12595630. [e]