Clotrimazole: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>Caesar Schinas
m (Bot: Replacing medical templates with CZMed)
mNo edit summary
 
Line 51: Line 51:


== References and external links ==
== References and external links ==
{{CZMed}}
{{CZMed}}[[Category:Suggestion Bot Tag]]

Latest revision as of 17:01, 29 July 2024

This article is developing and not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.
Clotrimazole.jpg
clotrimazole
IUPAC name: 1-[(2-chlorophenyl)-di(phenyl)methyl]imidazole
Synonyms: clotrimazol, chlotrimazole
Formula: C22H17ClN2

 Uses: antifungal drug

 Properties: azole compound

 Hazards: see side effects & drug interactions

Mass (g/mol): CAS #:
344.8368 23593-75-1


Clotrimazole, also called clotrimazol and chlotrimazole, is a broad-spectrm azole-based antifungal drug sold under many trade names. It is used to treat vaginal yeast infections, oropharyngeal candidiasis, and fungal infections such as ringworm, athlete's foot and jock itch. It is also used in combination with betamethasone in the treatment of cutaneous tinea infections.

Mechanism of action

Like other azole-based antifungal drugs, clotrimazole increases cell permeability by interfering with the conversion of lanosterol to ergostol, a critical component in fungal cell membranes, by inhibiting the enzyme 14-alpha-methylase, a P-450 enzyme. It is most effective against growing and dividing organisms.

Brand names

  • Canesten®
  • Canestine®
  • Canifug®
  • Cimitidine®
  • Clotrimaderm®
  • Empecid®
  • FemCare®
  • Gyne-Lotrimin 3®
  • Gyne-Lotrimin®
  • Gyne-Lotrimin ®
  • Gynix®
  • Lotrimin®
  • Mono-baycuten
  • Mycelax®
  • Mycelex®
  • Mycelex 7®
  • Mycelex G ®
  • Mycelex Troches®
  • Mycelex-7®
  • Myclo®
  • Myclo-Gyne®
  • Mycosporin®
  • Mykosporin®
  • Neo-Zol Cream®
  • Trimysten®
  • Trivagizole 3®
  • Veltrim®

References and external links

The most up-to-date information about Clotrimazole and other drugs can be found at the following sites.