Midodrine: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>David E. Volk
 
mNo edit summary
 
(14 intermediate revisions by 4 users not shown)
Line 1: Line 1:
{{subpages}}
{{subpages}}
[[Image:Midodrine structure.jpg|right|thumb|200px|{{#ifexist:Template:Midodrine structure.jpg/credit|{{Midodrine structure.jpg/credit}}<br/>|}}Midodrine.]]
{{Image|Midodrine structure.jpg|right|200px|Midodrine.}}  


'''Mitodrine''', or midodrina or midodrinum, is an ethanolamine derivative that is an adrenergic alpha agonist used as a vasoconstrictor agent in the treatment of [[hypotension]] (low blood pressure).  It is sold under the brand name '''ProAmatine'''.  One of its major metabolites, desglymidodrine, formed by the desglycination of midodrine, is an alpha1-agonist and is the active substance associated with this drug.  In patients with orthostatic hypotension, it raises the systolic and diastolic blood pressure in standing, sitting and supine positions. Activation of the alpha-adrenergic receptors in the arteriolar and venous vasculature increases vascular tone and elevates the blood pressure.  It does not stimulate cardiac beta-adrenergic receptors.  Symptoms of overdose include [[hypertension]], goosebumps ([[piloerection]]), urinary retention and a sensation of coldness.  Its chemical IUPAC name is 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide, and its chemical formula is C<sub>12</sub>H<sub>18</sub>N<sub>2</sub>O<sub>4</sub>.
'''Midodrine''', or midodrina or midodrinum, is an ethanolamine derivative that is an alpha-1 [[adrenergic receptor]] agonist used as a vasoconstrictor agent in the treatment of [[hypotension]] (low blood pressure).  Its chemical IUPAC name is 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide, and its chemical formula is C<sub>12</sub>H<sub>18</sub>N<sub>2</sub>O<sub>4</sub>. It is sold under the brand name '''ProAmatine'''®.  One of its major metabolites, desglymidodrine, formed by the desglycination of midodrine, is an alpha1-agonist and is the active substance associated with this drug.


== Drug interactions ==
In patients with [[orthostatic hypotension]], it raises the systolic and diastolic blood pressure in standing, sitting and supine positions. Activation of the alpha-1 [[adrenergic receptor]]s in the arteriolar and venous vasculature increases vascular tone and elevates the blood pressure.  It does not stimulate cardiac beta-[[adrenergic receptor]]s.  
Although increased arterial pressure occurs when this drug is used in combination with many other drugs, possible ''hypertensive crisis'' can occur when taken with [[tranylcypromine]], [[rasagiline]], [[phenelzine]] and [[isocarboxazid]]. Less dangerous increases in arterial pressure may occur when taken in combination with:


*Betamethasone 
==Adverse effects==
*Cortisone acetate
Symptoms of overdose include [[hypertension]], [[piloerection|goosebumps]], urinary retention and a sensation of coldness.
*Dexamethasone
*Dobutamine
*Dopamine
*Ephedra
*Ephedrine
*Epinephrine
*Fenoterol
*Fludrocortisone 
*Hydrocortisone
*Isoproterenol
*Mephentermine
*Methoxamine
*Metaraminol
Methylprednisolone
*Prednisolone
*Prednisone
*Norepinephrine
*Orciprenaline 
*Paramethasone
*Phenylephrine 
*Pseudoephedrine
*Pirbuterol
*Phenylpropanolamine
*Procaterol
*Salbutamol 
*Terbutaline
*Triamcinolone


=== Drug interactions ===
Although increased arterial pressure occurs when this drug is used in combination with many other drugs, possible ''hypertensive crisis'' can occur when taken with [[tranylcypromine]], [[rasagiline]], [[phenelzine]] and [[isocarboxazid]].  Less dangerous increases in arterial pressure may occur when taken in combination with:
<div class= style="-moz-column-count:3; column-count:3;">
* [[Betamethasone]] 
* [[Cortisone acetate]]
* [[Dexamethasone]]
* [[Dobutamine]]
* [[Dopamine]]
* [[Ephedra]]
* [[Ephedrine]]
* [[Epinephrine]]
* [[Fenoterol]]
* [[Fludrocortisone]] 
* [[Hydrocortisone]]
* [[Isoproterenol]]
* [[Mephentermine]]
* [[Methoxamine]]
* [[Metaraminol]]
* [[Methylprednisolone]]
* [[Norepinephrine]]
* [[Orciprenaline]]
* [[Paramethasone]]
* [[Phenylephrine]]
* [[Prednisolone]]
* [[Prednisone]]
* [[Pseudoephedrine]]
* [[Pirbuterol]]
* [[Phenylpropanolamine]]
* [[Procaterol]]
* [[Salbutamol]] 
* [[Terbutaline]]
* [[Triamcinolone]]
</div>


== External Links ==
== External Links ==
*{{DailyMed}
{{CZMed}}[[Category:Suggestion Bot Tag]]
* Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00211

Latest revision as of 07:01, 19 September 2024

This article is developing and not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.
(CC) Image: David E. Volk
Midodrine.

Midodrine, or midodrina or midodrinum, is an ethanolamine derivative that is an alpha-1 adrenergic receptor agonist used as a vasoconstrictor agent in the treatment of hypotension (low blood pressure). Its chemical IUPAC name is 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide, and its chemical formula is C12H18N2O4. It is sold under the brand name ProAmatine®. One of its major metabolites, desglymidodrine, formed by the desglycination of midodrine, is an alpha1-agonist and is the active substance associated with this drug.

In patients with orthostatic hypotension, it raises the systolic and diastolic blood pressure in standing, sitting and supine positions. Activation of the alpha-1 adrenergic receptors in the arteriolar and venous vasculature increases vascular tone and elevates the blood pressure. It does not stimulate cardiac beta-adrenergic receptors.

Adverse effects

Symptoms of overdose include hypertension, goosebumps, urinary retention and a sensation of coldness.

Drug interactions

Although increased arterial pressure occurs when this drug is used in combination with many other drugs, possible hypertensive crisis can occur when taken with tranylcypromine, rasagiline, phenelzine and isocarboxazid. Less dangerous increases in arterial pressure may occur when taken in combination with:

External Links

The most up-to-date information about Midodrine and other drugs can be found at the following sites.