Vancomycin
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Pharmacology
The half life in normal individuals is 4-6 hours.[1]
Adverse effects
Thrombocytopenia
Vancomycin may cause immune thrombocytopenia.[2]
Acute kidney injury
Vancomycin is associated with acute kidney injury if trough levels are above 15 microg/mL.[3] To avoid this, the blood levels of vancomycin should be monitored.[4][5] Recommended trough levels are 15–20 mg/L.[6]
References
- ↑ DailyMed. vancomycin hydrochloride (Vancomycin Hydrochloride) injection, solution. Retrieved on 2008-01-06.
- ↑ Von Drygalski A, Curtis BR, Bougie DW, et al (2007). "Vancomycin-induced immune thrombocytopenia". N. Engl. J. Med. 356 (9): 904–10. DOI:10.1056/NEJMoa065066. PMID 17329697. Research Blogging.
- ↑ Hidayat LK, Hsu DI, Quist R, Shriner KA, Wong-Beringer A (2006). "High-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicity". Arch. Intern. Med. 166 (19): 2138–44. DOI:10.1001/archinte.166.19.2138. PMID 17060545. Research Blogging.
- ↑ Welty TE, Copa AK (1994). "Impact of vancomycin therapeutic drug monitoring on patient care". Ann Pharmacother 28 (12): 1335–9. PMID 7696720. [e]
- ↑ Iwamoto T, Kagawa Y, Kojima M (2003). "Clinical efficacy of therapeutic drug monitoring in patients receiving vancomycin". Biol. Pharm. Bull. 26 (6): 876–9. PMID 12808304. [e]
- ↑ Rybak M, Lomaestro B, Rotschafer JC, et al (January 2009). "Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists". Am J Health Syst Pharm 66 (1): 82–98. DOI:10.2146/ajhp080434. PMID 19106348. Research Blogging. Journal Watch summary
External links
for injection 3625 - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).