Penciclovir: Difference between revisions
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|molname=penciclovir | |molname=penciclovir | ||
|synonyms= PE2, penciclovirum | |synonyms= '''Denavir®, PE2, penciclovirum''' | ||
|molformula= C<sub>10</sub>H<sub>15</sub>N<sub>5</sub>O<sub>3</sub> | |molformula= C<sub>10</sub>H<sub>15</sub>N<sub>5</sub>O<sub>3</sub> | ||
|molmass= 253.2578 | |molmass= 253.2578 | ||
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'''Penciclovir''' ('''PE2''') or '''penciclovirum''', is a [[guanosine]] analog, [[antiviral drug]] used to treat [[herpesvirus]]es and is the active metabolite of the prodrug [[famciclovir]]. It is sold under the brand name '''Denavir®'''. The longer [[half-life]] of penciclovir triphosphate in herpes-infected cells (10-20 hrs), compared to that of [[acyclovir]] (0,7 -1 hr), may be responsible for its ehanced results. | '''Penciclovir''' ('''PE2''') or '''penciclovirum''', is a [[guanosine]] analog, [[antiviral drug]] used to treat [[herpesvirus]]es and is the active metabolite of the prodrug [[famciclovir]]. It is sold under the brand name '''Denavir®'''. The longer [[half-life]] of penciclovir triphosphate in herpes-infected cells (10-20 hrs), compared to that of [[acyclovir]] (0,7 -1 hr), may be responsible for its ehanced results. | ||
The triphosphate form competes with [[deoxyguanosine]] triphosphate for incorporation into viral DNA. It only effects DNA synthesis of only those cells infected with [[herpes simplex virus]] (HSV). | The triphosphate form competes with [[deoxyguanosine]] triphosphate for incorporation into viral DNA. It only effects DNA synthesis of only those cells infected with [[herpes simplex virus]] (HSV). | ||
== Chemistry == | == Chemistry == | ||
Revision as of 12:56, 24 March 2008
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| penciclovir | |||||||
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| Uses: | herpes viruses | ||||||
| Properties: | guanosine analog | ||||||
| Hazards: | see drug interactions | ||||||
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Penciclovir (PE2) or penciclovirum, is a guanosine analog, antiviral drug used to treat herpesviruses and is the active metabolite of the prodrug famciclovir. It is sold under the brand name Denavir®. The longer half-life of penciclovir triphosphate in herpes-infected cells (10-20 hrs), compared to that of acyclovir (0,7 -1 hr), may be responsible for its ehanced results. The triphosphate form competes with deoxyguanosine triphosphate for incorporation into viral DNA. It only effects DNA synthesis of only those cells infected with herpes simplex virus (HSV).
Chemistry
The IUPAC chemical name of penciclovir is 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin-6-one, and it has chemical formula C10H15N5O3, giving it a molecular mass of 253.2578 g/mol. It is an analog of the natural nucleotide guanosine. The prodrug famciclovir is an analog of this drug.
External links
- Penciclovir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Template:MedMaster
- Template:DrugBank