Pharyngitis

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In medicine, pharyngitis is an upper respiratory tract infection that is "inflammation of the throat (pharynx)."[1]

Causes

Viral

The majority of pharyngtis is caused by viral infection.

Bacterial

Group A β-hemolytic streptococcus (streptococcus pyogenes).

Fusobacterium necrophorum may be as common as group A β-hemolytic streptococcus and can cause Lemierre syndrome.[2] Lemierre syndrome is "suppurative thrombophlebitis of the internal jugular vein, bacteremia, and metastatic infections."</ref name="pmid19949147">

Chemical and physical agents

Diagnosis

Diagnosis has been reviewed by the Rational Clinical Examination who noted the Centor criteria (Centor criteria (fever, no cough, tonsilar exudate, tender anterior cervical lymph nodes).[3]

Differential diagnosis

  • Angioedema [r]: Allergic skin reaction causing localized redness, swelling, and itching. [e]

Pharyngitis caused by Fusobacterium necrophorum may lead to Lemierre syndrome.[2]

Treatment

Losenges with amylmetacresol and 2,4-dichlorobenzyl alcohol may help.[4]

Corticosteroids, such as prednisone 60 mg by mouth for one or two days may reduce symptoms among patients with severe pharyngitis.[5][6]

References

  1. Anonymous (2024), Pharyngitis (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Jump up to: 2.0 2.1 Centor, Robert (2009-12-01). "Expand the Pharyngitis Paradigm for Adolescents and Young Adults". Annals of Internal Medicine 151 (11): 812-815. PMID 19949147. Retrieved on 2009-12-01. Cite error: Invalid <ref> tag; name "pmid19949147" defined multiple times with different content
  3. Ebell MH, Smith MA, Barry HC, Ives K, Carey M (2000). "The rational clinical examination. Does this patient have strep throat?". JAMA 284 (22): 2912-8. PMID 11147989[e]
  4. McNally D, Simpson M, Morris C, Shephard A, Goulder M (2010). "Rapid relief of acute sore throat with AMC/DCBA throat lozenges: randomised controlled trial.". Int J Clin Pract 64 (2): 194-207. DOI:10.1111/j.1742-1241.2009.02230.x. PMID 19849767. Research Blogging.
  5. Hayward G, Thompson M, Heneghan C, Perera R, Del Mar C, Glasziou P (2009). "Corticosteroids for pain relief in sore throat: systematic review and meta-analysis.". BMJ 339: b2976. PMID 19661138. PMC PMC2722696.
  6. Kiderman A, Yaphe J, Bregman J, Zemel T, Furst AL (March 2005). "Adjuvant prednisone therapy in pharyngitis: a randomised controlled trial from general practice". Br J Gen Pract 55 (512): 218–21. PMID 15808038. PMC 1463093[e]