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Measles
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{{Taxobox | color=violet
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| name = x
Measles
| virus_group = x
Classification and external resources
| familia = x
| genus = x
How measles affects the skin.
| sero_complex = x
ICD-10 B05..-
| subdivision_ranks = Species
ICD-9 055
| subdivision =
DiseasesDB 7890
}}
MedlinePlus 001569
eMedicine derm/259  ped/1388
Measles virus


==Description and significance==
Describe the appearance, habitat, etc. of the organism, and why it is important enough to have its genome sequenced.  Describe how and where it was isolated.
Include a picture or two (with sources) if you can find them.


==Genome structure==
Measles virus
Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?
Virus classification
Does it have any plasmids? Are they important to the organism's lifestyle?
Group: Group V ((-)ssRNA)
Order: Mononegavirales
   
Family: Paramyxoviridae
   
Genus: Morbillivirus
   
   
Type species
Measles virus
   
Measles, also known as rubeola, is a disease caused by a virus, specifically a paramyxovirus of the genus Morbillivirus.


==Cell structure and metabolism==
Measles is spread through respiration (contact with fluids from an infected person's nose and mouth, either directly or through aerosol transmission), and is highly contagious—90% of people without immunity sharing a house with an infected person will catch it. Airborne precautions should be taken for all suspected cases of measles.
Describe any interesting features and/or cell structures; how it gains energy; what important molecules it produces.


==Ecology==
The incubation period usually lasts for 4–12 days (during which there are no symptoms). Infected people remain contagious from the appearance of the first symptoms until 3–5 days after the rash appears.
Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.


==Pathology==
Reports of measles go as far back to at least 600 B.C. however, the first scientific description of the disease and its distinction from smallpox is attributed to the Persian physician Ibn Razi (Rhazes) 860-932 who published a book entitled "The Book of Smallpox and Measles" (in Arabic: Kitab fi al-jadari wa-al-hasbah). In roughly the last 150 years, measles has been estimated to have killed about 200 million people worldwide.[1] In 1954, the virus causing the disease was isolated from an 11-year old boy from the US, David Edmonston, and adapted and propagated on chick embryo tissue culture.[2] To date, 21 strains of the measles virus have been identified.[3] Licensed vaccines to prevent the disease became available in 1963.
How does this organism cause disease?  Human, animal, plant hosts?  Virulence factors, as well as patient symptoms.


==Application to Biotechnology==
German measles is an unrelated condition caused by the rubella virus.
Does this organism produce any useful compounds or enzymes?  What are they and how are they used?


==Current Research==
Contents [hide]
1 Symptoms
2 Diagnosis and treatment
3 Transmission
4 Complications
5 Public health
6 Worldwide MMR Eradication
7 See also
8 References
9 External links


Enter summaries of the most recent research here--at least three required


==References==
[edit] Symptoms
<references/>
The classical symptoms of measles include a fever for at least three days, the three Cs—cough, coryza (runny nose) and conjunctivitis (red eyes). The fever may reach up to 40° Celsius (104° Fahrenheit). Koplik's spots seen inside the mouth are pathognomonic (diagnostic) for measles but are not often seen, even in real cases of measles, because they are transient and may disappear within a day of arising.


Summary of measles virus
The characteristic measles rash is classically described as a generalized, maculopapular, erythematous rash that begins several days after the fever starts. It starts on the head before spreading to cover most of the body, often causing itching. The rash is said to "stain", changing colour from red to dark brown, before disappearing.[citation needed]


Measles is a highly contagious viral infection characterized by a fever and a red, bumpy rash.


What is going on in the body?
[edit] Diagnosis and treatment
Measles is acquired by coming into contact with infected respiratory secretions and droplets. Infected people can spread it when they cough, sneeze or wipe their noses. Over the last four decades, widespread use of a highly effective measles [[vaccine]] and aggressive outbreak control have resulted in the elimination of measles virus circulation in the United States. However, measles is imported into this country periodically by travelers, visitors, and immigrants.  
Clinical diagnosis of measles requires a history of fever of at least three days together with at least one of the three Cs. Observation of Koplik's spots is also diagnostic of measles.


What are the signs and symptoms of the infection?
Alternatively, laboratory diagnosis of measles can be done with confirmation of positive measles IgM antibodies or isolation of measles virus RNA from respiratory specimens. In cases of measles infection following secondary vaccine failure IgM antibody may not be present. In these cases serological confirmation may be made by showing IgG antibody rises by Enzyme immunoasay or complement fixation. In children, where phlebotomy is inappropriate, saliva can be collected for salivary measles specific IgA test.[citation needed]
Symptoms usually begin about 1 to 1-1/2 weeks after acquiring the virus. The symptoms can include:
• A fever, usually 39-40 degrees C or higher (103 -104 degree F)
• A red, slightly bumpy rash.
• cough.
• Tiny white spots inside the mouth (known as "Koplik's spots")
• Runny nose (Coryza)
• [[Conjunctivitis]], also known as pink or red eye. Conjunctivitis is an inflammation of the [[mucous membrane]] that lines the inner part of the eyelid.
*Sometimes, measles cases can be complicated by [[ear infections]], [[croup]], or [[pneumonia]]. About 0.1% of patients can contract [[encephalitis]], an infection of the brain after becoming infected with measles. Encephalitis can result in [[brain]] damage and, sometimes, death.


What are the causes and risks of the infection?
Positive contact with other patients known to have measles adds strong epidemiological evidence to the diagnosis.
Measles is caused by the measles virus, which belongs to the Paramyxovirus family of viruses. Anyone who has not had measles before, and has not been immunized, is at risk for measles. Measles is so highly communicable by airborne spread that cases have been shown to result from sitting in a waiting room occupied by a measles case hours before.  


What can be done to prevent the infection?
There is no specific treatment or antiviral therapy for uncomplicated measles. Most patients with uncomplicated measles will recover with rest and supportive treatment.
The measles vaccine is very effective at preventing measles in immunized people. The vaccine is usually combined with the rubella, mumps, and chickenpox vaccines and given as one shot, called the MMRV vaccine. Side effects of the MMRV vaccine can include:
• fever and rash
• joint pain
• allergic reactions
Other side effects are rare. The vaccine should not be given to pregnant women or to women who are planning on getting pregnant in the 3 months following immunization. Another way to prevent the spread of infection is to isolate the infected person. An infected person with a normal immune system should stay home from school or work for 4 days after the rash appears. An infected person with autoimmune problems, where the body attacks its own tissues, may be contagious for even longer. In some circumstances, susceptible individuals who have been exposed to measles are also isolated, until it is determined whether they will come down with the infection. Some people with autoimmune problems or other immune system disorders should not have the measles vaccine. If these unprotected people are exposed to an infected person, they should receive immune globulin prophylaxis, an injection of disease-fighting proteins.  


How is the infection diagnosed?
Some patients will develop pneumonia as a sequela to the measles. Histologically, a unique cell can be found in the paracortical region of hyperplastic lymph nodes in patients affected with this condition. This cell, known as the Warthin-Finkeldey cell, is a multinucleated giant with eosinophilic cytoplasmic and nuclear inclusions.[citation needed]
A measles case is usually confirmed with a blood test for measles antibodies, though if a person with symptoms is a known contact of a confirmed case, a clinical diagnosis is sufficient. The measles virus can be cultured from infected respiratory secretions, the eye, the blood, or the urine during the acute phase of the illness. The usual reason to recover measles virus from a person is to identify the viral strain in order to trace the source of an importation.
 
 
[edit] Transmission
The measles is a highly contagious airborne pathogen which spreads primarily via the respiratory system. The virus is transmitted in respiratory secretions, and can be passed from person to person via aerosol droplets containing virus particles, such as those produced by a coughing patient. Once transmission occurs, the virus infects the epithelial cells of its new host, and may also replicate in the urinary tract, lymphatic system, conjunctivae, blood vessels, and central nervous system.[4]
 
Humans are the only known natural hosts of measles, although the virus can infect some non-human primate species.
 
 
[edit] Complications
Complications with measles are relatively common, ranging from relatively mild and less serious diarrhea, to pneumonia and encephalitis (subacute sclerosing panencephalitis), corneal ulceration leading to corneal scarring[5] Complications are usually more severe amongst adults who catch the virus.
 
The fatality rate from measles for otherwise healthy people in developed countries is low: approximately 1 death per thousand cases. In underdeveloped nations with high rates of malnutrition and poor healthcare, fatality rates of 10 percent are common. In immunocompromised patients, the fatality rate is approximately 30 percent.
 
 
[edit] Public health
A scene from 1949's Polka-Dot Puss, where Tom and Jerry are put in quarantine after getting the measles. The disease was common during the time when the cartoon was made.Measles is a significant infectious disease because, while the rate of complications is not high, the disease itself is so infectious that the sheer number of people who would suffer complications in an outbreak amongst non-immune people would quickly overwhelm available hospital resources. If vaccination rates fall, the number of non-immune persons in the community rises, and the risk of an outbreak of measles consequently rises.
 
In developed countries, most children are immunized against measles by the age of 18 months, generally as part of a three-part MMR vaccine (measles, mumps, and rubella). The vaccination is generally not given earlier than this because children younger than 18 months usually retain anti-measles immunoglobulins (antibodies) transmitted from the mother during pregnancy. A "booster" vaccine is then given between the ages of four and five. Vaccination rates have been high enough to make measles relatively uncommon. Even a single case in a college dormitory or similar setting is often met with a local vaccination program, in case any of the people exposed are not already immune. In developing countries, measles remains common.
 
Unvaccinated populations are at risk for the disease. After vaccination rates dropped in northern Nigeria in the early 2000s due to religious and political objections, the number of cases rose significantly, and hundreds of children died.[6] A 2005 measles outbreak in Indiana was attributed to children whose parents refused vaccination.[7] In the early 2000s the MMR vaccine controversy in the United Kingdom regarding a potential link between the combined MMR vaccine (vaccinating children from mumps, measles and rubella) and autism prompted a comeback in the measles party, where parents deliberately infect the child with measles to build up the child's immunity without an injection. This practice poses many health risks to the child, and has been discouraged by the public health authorities.[8] Scientific evidence provides no support for the hypothesis that MMR plays a role in causing autism.[9] Declining immunisation rates in the UK are the probable cause of a significant increase of cases of measles, 2006 being the highest on record, and 2007 already showing an increase on the previous year.[10]
 
According to the World Health Organization (WHO), measles is a leading cause of vaccine preventable childhood mortality. Worldwide, the fatality rate has been significantly reduced by partners in the Measles Initiative: the American Red Cross, the United States Centers for Disease Control and Prevention (CDC), the United Nations Foundation, UNICEF and the World Health Organization (WHO). Globally, measles deaths are down 60 percent, from an estimated 873,000 deaths in 1999 to 345,000 in 2005. Africa has seen the most success, with annual measles deaths falling by 75 percent in just 5 years, from an estimated 506,000 to 126,000.[11]
 
The joint press release by members of the Measles Initiative brings to light another benefit of the fight against measles: "Measles vaccination campaigns are contributing to the reduction of child deaths from other causes. They have become a channel for the delivery of other life-saving interventions, such as bed nets to protect against malaria, de-worming medicine and vitamin A supplements. Combining measles immunization with other health interventions is a contribution to the achievement of Millennium Development Goal Number 4: a two-thirds reduction in child deaths between 1990 and 2015."[11]
 
 
[edit] Worldwide MMR Eradication
(Not to be confused with the World Health Organization's Measles Initiative)
 
Most recently, in 2007, the country Japan has become a nidus for measles. Japan has suffered a record number of cases, and a number of universities and other institutions in the country have closed in an attempt to contain the outbreak.[1]
 
In the 1990s, the governments of the Americas, along with the Pan American Health Organization, launched a plan to eradicate the three MMR vaccine diseases - measles, mumps, and rubella - from the region.
 
Indigenous measles has been eliminated in North, Central, and South America; the last endemic case in the region was reported on November 12, 2002. [12]
 
Outbreaks are still occurring, however, following importations of measles viruses from other world regions. For example, in June 2006, there was an outbreak in Boston which resulted from a resident who had recently visited India.[13] In 2005, there was an outbreak in a non-immunized population in Indiana and Illinois, transmitted by an Indiana girl who visited Romania without being vaccinated. In Michigan in the fall of 2007, a confirmed case of measles occurred in a girl who had been vaccinated and who apparently contracted it overseas. There were at least 6 other suspected cases, all among children who had been vaccinated.
 
There are also plans underway to eliminate rubella from the region by 2010.[12] As of 2006, endemic cases were still being reported in Bolivia, Brazil, Colombia, Guatemala, Mexico, Peru, and Venezuela, they are currently vaccinating Dominican Republic.[citation needed]
 
While some have proposed eradication,[14] none is likely to take place until, at least, after the worldwide eradication of Poliomyelitis.
 
 
[edit] See also
Infectious disease
List of epidemics
MMR vaccine
 
[edit] References
^ Torrey EF and Yolken RH. 2005. Their bugs are worse than their bite. Washington Post, April 3, p. B01.
^ Live attenuated measles vaccine. EPI Newsl. 1980 Feb;2(1):6.
^ Rima BK, Earle JA, Yeo RP, Herlihy L, Baczko K, ter Muelen V, Carabana J, Caballero M, Celma ML, Fernandez-Munoz R 1995 Temporal and geographical distribution of measles virus genotypes. J Gen Virol 76:11731180.
^ Flint SJ, Enquist LW, Racaniello VR, and AM Skalka. Principles of Virology, 2nd edition: Molecular Biology, Pathogenesis, and Control of Animal Viruses. 
^ http://www.iceh.org.uk/files/tsno4/resources/no04.doc
^ "Measles kills more than 500 children so far in 2005", IRIN, 2005-03-21. Retrieved on 2007-08-13. 
^ Parker A, Staggs W, Dayan G et al. (2006). "Implications of a 2005 measles outbreak in Indiana for sustained elimination of measles in the United States". N Engl J Med 355 (5): 447–55. PMID 16885548. 
^ Dillner L. "The return of the measles party", Guardian, 2001-07-26. Retrieved on 2007-08-13. 
^ Rutter M (2005). "Incidence of autism spectrum disorders: changes over time and their meaning". Acta Paediatr 94 (1): 2–15. PMID 15858952. 
^ Telegraph article on increasing cases of measles
^ a b UNICEF Joint Press Release
^ a b paho.org. Retrieved on 2007-12-05.
^ Measles outbreak shows a global threat - The Boston Globe. Retrieved on 2007-12-05.
^ The Viral Eradication Trinity. Retrieved on 2007-12-05.

Revision as of 23:33, 10 April 2008

Measles From Wikipedia, the free encyclopedia Jump to: navigation, search Measles Classification and external resources

How measles affects the skin. ICD-10 B05..- ICD-9 055 DiseasesDB 7890 MedlinePlus 001569 eMedicine derm/259 ped/1388 Measles virus


Measles virus Virus classification Group: Group V ((-)ssRNA) Order: Mononegavirales

Family: Paramyxoviridae

Genus: Morbillivirus


Type species Measles virus

Measles, also known as rubeola, is a disease caused by a virus, specifically a paramyxovirus of the genus Morbillivirus.

Measles is spread through respiration (contact with fluids from an infected person's nose and mouth, either directly or through aerosol transmission), and is highly contagious—90% of people without immunity sharing a house with an infected person will catch it. Airborne precautions should be taken for all suspected cases of measles.

The incubation period usually lasts for 4–12 days (during which there are no symptoms). Infected people remain contagious from the appearance of the first symptoms until 3–5 days after the rash appears.

Reports of measles go as far back to at least 600 B.C. however, the first scientific description of the disease and its distinction from smallpox is attributed to the Persian physician Ibn Razi (Rhazes) 860-932 who published a book entitled "The Book of Smallpox and Measles" (in Arabic: Kitab fi al-jadari wa-al-hasbah). In roughly the last 150 years, measles has been estimated to have killed about 200 million people worldwide.[1] In 1954, the virus causing the disease was isolated from an 11-year old boy from the US, David Edmonston, and adapted and propagated on chick embryo tissue culture.[2] To date, 21 strains of the measles virus have been identified.[3] Licensed vaccines to prevent the disease became available in 1963.

German measles is an unrelated condition caused by the rubella virus.

Contents [hide] 1 Symptoms 2 Diagnosis and treatment 3 Transmission 4 Complications 5 Public health 6 Worldwide MMR Eradication 7 See also 8 References 9 External links


[edit] Symptoms The classical symptoms of measles include a fever for at least three days, the three Cs—cough, coryza (runny nose) and conjunctivitis (red eyes). The fever may reach up to 40° Celsius (104° Fahrenheit). Koplik's spots seen inside the mouth are pathognomonic (diagnostic) for measles but are not often seen, even in real cases of measles, because they are transient and may disappear within a day of arising.

The characteristic measles rash is classically described as a generalized, maculopapular, erythematous rash that begins several days after the fever starts. It starts on the head before spreading to cover most of the body, often causing itching. The rash is said to "stain", changing colour from red to dark brown, before disappearing.[citation needed]


[edit] Diagnosis and treatment Clinical diagnosis of measles requires a history of fever of at least three days together with at least one of the three Cs. Observation of Koplik's spots is also diagnostic of measles.

Alternatively, laboratory diagnosis of measles can be done with confirmation of positive measles IgM antibodies or isolation of measles virus RNA from respiratory specimens. In cases of measles infection following secondary vaccine failure IgM antibody may not be present. In these cases serological confirmation may be made by showing IgG antibody rises by Enzyme immunoasay or complement fixation. In children, where phlebotomy is inappropriate, saliva can be collected for salivary measles specific IgA test.[citation needed]

Positive contact with other patients known to have measles adds strong epidemiological evidence to the diagnosis.

There is no specific treatment or antiviral therapy for uncomplicated measles. Most patients with uncomplicated measles will recover with rest and supportive treatment.

Some patients will develop pneumonia as a sequela to the measles. Histologically, a unique cell can be found in the paracortical region of hyperplastic lymph nodes in patients affected with this condition. This cell, known as the Warthin-Finkeldey cell, is a multinucleated giant with eosinophilic cytoplasmic and nuclear inclusions.[citation needed]


[edit] Transmission The measles is a highly contagious airborne pathogen which spreads primarily via the respiratory system. The virus is transmitted in respiratory secretions, and can be passed from person to person via aerosol droplets containing virus particles, such as those produced by a coughing patient. Once transmission occurs, the virus infects the epithelial cells of its new host, and may also replicate in the urinary tract, lymphatic system, conjunctivae, blood vessels, and central nervous system.[4]

Humans are the only known natural hosts of measles, although the virus can infect some non-human primate species.


[edit] Complications Complications with measles are relatively common, ranging from relatively mild and less serious diarrhea, to pneumonia and encephalitis (subacute sclerosing panencephalitis), corneal ulceration leading to corneal scarring[5] Complications are usually more severe amongst adults who catch the virus.

The fatality rate from measles for otherwise healthy people in developed countries is low: approximately 1 death per thousand cases. In underdeveloped nations with high rates of malnutrition and poor healthcare, fatality rates of 10 percent are common. In immunocompromised patients, the fatality rate is approximately 30 percent.


[edit] Public health

A scene from 1949's Polka-Dot Puss, where Tom and Jerry are put in quarantine after getting the measles. The disease was common during the time when the cartoon was made.Measles is a significant infectious disease because, while the rate of complications is not high, the disease itself is so infectious that the sheer number of people who would suffer complications in an outbreak amongst non-immune people would quickly overwhelm available hospital resources. If vaccination rates fall, the number of non-immune persons in the community rises, and the risk of an outbreak of measles consequently rises.

In developed countries, most children are immunized against measles by the age of 18 months, generally as part of a three-part MMR vaccine (measles, mumps, and rubella). The vaccination is generally not given earlier than this because children younger than 18 months usually retain anti-measles immunoglobulins (antibodies) transmitted from the mother during pregnancy. A "booster" vaccine is then given between the ages of four and five. Vaccination rates have been high enough to make measles relatively uncommon. Even a single case in a college dormitory or similar setting is often met with a local vaccination program, in case any of the people exposed are not already immune. In developing countries, measles remains common.

Unvaccinated populations are at risk for the disease. After vaccination rates dropped in northern Nigeria in the early 2000s due to religious and political objections, the number of cases rose significantly, and hundreds of children died.[6] A 2005 measles outbreak in Indiana was attributed to children whose parents refused vaccination.[7] In the early 2000s the MMR vaccine controversy in the United Kingdom regarding a potential link between the combined MMR vaccine (vaccinating children from mumps, measles and rubella) and autism prompted a comeback in the measles party, where parents deliberately infect the child with measles to build up the child's immunity without an injection. This practice poses many health risks to the child, and has been discouraged by the public health authorities.[8] Scientific evidence provides no support for the hypothesis that MMR plays a role in causing autism.[9] Declining immunisation rates in the UK are the probable cause of a significant increase of cases of measles, 2006 being the highest on record, and 2007 already showing an increase on the previous year.[10]

According to the World Health Organization (WHO), measles is a leading cause of vaccine preventable childhood mortality. Worldwide, the fatality rate has been significantly reduced by partners in the Measles Initiative: the American Red Cross, the United States Centers for Disease Control and Prevention (CDC), the United Nations Foundation, UNICEF and the World Health Organization (WHO). Globally, measles deaths are down 60 percent, from an estimated 873,000 deaths in 1999 to 345,000 in 2005. Africa has seen the most success, with annual measles deaths falling by 75 percent in just 5 years, from an estimated 506,000 to 126,000.[11]

The joint press release by members of the Measles Initiative brings to light another benefit of the fight against measles: "Measles vaccination campaigns are contributing to the reduction of child deaths from other causes. They have become a channel for the delivery of other life-saving interventions, such as bed nets to protect against malaria, de-worming medicine and vitamin A supplements. Combining measles immunization with other health interventions is a contribution to the achievement of Millennium Development Goal Number 4: a two-thirds reduction in child deaths between 1990 and 2015."[11]


[edit] Worldwide MMR Eradication (Not to be confused with the World Health Organization's Measles Initiative)

Most recently, in 2007, the country Japan has become a nidus for measles. Japan has suffered a record number of cases, and a number of universities and other institutions in the country have closed in an attempt to contain the outbreak.[1]

In the 1990s, the governments of the Americas, along with the Pan American Health Organization, launched a plan to eradicate the three MMR vaccine diseases - measles, mumps, and rubella - from the region.

Indigenous measles has been eliminated in North, Central, and South America; the last endemic case in the region was reported on November 12, 2002. [12]

Outbreaks are still occurring, however, following importations of measles viruses from other world regions. For example, in June 2006, there was an outbreak in Boston which resulted from a resident who had recently visited India.[13] In 2005, there was an outbreak in a non-immunized population in Indiana and Illinois, transmitted by an Indiana girl who visited Romania without being vaccinated. In Michigan in the fall of 2007, a confirmed case of measles occurred in a girl who had been vaccinated and who apparently contracted it overseas. There were at least 6 other suspected cases, all among children who had been vaccinated.

There are also plans underway to eliminate rubella from the region by 2010.[12] As of 2006, endemic cases were still being reported in Bolivia, Brazil, Colombia, Guatemala, Mexico, Peru, and Venezuela, they are currently vaccinating Dominican Republic.[citation needed]

While some have proposed eradication,[14] none is likely to take place until, at least, after the worldwide eradication of Poliomyelitis.


[edit] See also Infectious disease List of epidemics MMR vaccine

[edit] References ^ Torrey EF and Yolken RH. 2005. Their bugs are worse than their bite. Washington Post, April 3, p. B01. ^ Live attenuated measles vaccine. EPI Newsl. 1980 Feb;2(1):6. ^ Rima BK, Earle JA, Yeo RP, Herlihy L, Baczko K, ter Muelen V, Carabana J, Caballero M, Celma ML, Fernandez-Munoz R 1995 Temporal and geographical distribution of measles virus genotypes. J Gen Virol 76:11731180. ^ Flint SJ, Enquist LW, Racaniello VR, and AM Skalka. Principles of Virology, 2nd edition: Molecular Biology, Pathogenesis, and Control of Animal Viruses. ^ http://www.iceh.org.uk/files/tsno4/resources/no04.doc ^ "Measles kills more than 500 children so far in 2005", IRIN, 2005-03-21. Retrieved on 2007-08-13. ^ Parker A, Staggs W, Dayan G et al. (2006). "Implications of a 2005 measles outbreak in Indiana for sustained elimination of measles in the United States". N Engl J Med 355 (5): 447–55. PMID 16885548. ^ Dillner L. "The return of the measles party", Guardian, 2001-07-26. Retrieved on 2007-08-13. ^ Rutter M (2005). "Incidence of autism spectrum disorders: changes over time and their meaning". Acta Paediatr 94 (1): 2–15. PMID 15858952. ^ Telegraph article on increasing cases of measles ^ a b UNICEF Joint Press Release ^ a b paho.org. Retrieved on 2007-12-05. ^ Measles outbreak shows a global threat - The Boston Globe. Retrieved on 2007-12-05. ^ The Viral Eradication Trinity. Retrieved on 2007-12-05.