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In biology and medicine, S-adenosylmethionine is a "physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease."[1]

S-adenosylmethionine's role in treating liver disease is uncertain.[2]

S-adenosylmethionine may help osteoarthritis[3][4][5][6][7][8]; however, the limited research may be affected by publication bias.


  1. Anonymous (2015), S-adenosylmethionine (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Rambaldi A, Gluud C (2006). "S-adenosyl-L-methionine for alcoholic liver diseases". Cochrane Database Syst Rev (2): CD002235. DOI:10.1002/14651858.CD002235.pub2. PMID 16625556. Research Blogging.
  3. De Silva V, El-Metwally A, Ernst E, Lewith G, Macfarlane GJ, Arthritis Research UK Working Group on Complementary and Alternative Medicines (2011). "Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review.". Rheumatology (Oxford) 50 (5): 911-20. DOI:10.1093/rheumatology/keq379. PMID 21169345. Research Blogging.
  4. Hardy ML, Coulter I, Morton SC, et al (August 2003). "S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease". Evid Rep Technol Assess (Summ) (64): 1–3. PMID 12899148[e] ACP Journal Club review
  5. Najm WI, Reinsch S, Hoehler F, Tobis JS, Harvey PW (February 2004). "S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495"]. BMC Musculoskelet Disord 5: 6. DOI:10.1186/1471-2474-5-6. PMID 15102339. PMC 387830. Research Blogging.
  6. Müller-Fassbender H (November 1987). "Double-blind clinical trial of S-adenosylmethionine versus ibuprofen in the treatment of osteoarthritis". Am. J. Med. 83 (5A): 81–3. PMID 3318445[e]
  7. Vetter G (November 1987). "Double-blind comparative clinical trial with S-adenosylmethionine and indomethacin in the treatment of osteoarthritis". Am. J. Med. 83 (5A): 78–80. PMID 3318444[e]
  8. König B (November 1987). "A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis". Am. J. Med. 83 (5A): 89–94. PMID 3318447[e]