Propranolol

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propranolol
IUPAC name:
Synonyms:
Formula:

 Uses: hypertention;angina pectoris

 Properties: lipophilic

 Hazards: see side effects & drug interactions

Mass (g/mol): CAS #:


In medicine, propranolol is "a widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for myocardial infarction; arrhythmia; angina pectoris; hypertension; hyperthyroidism; migraine; pheochromocytoma; and anxiety but adverse effects instigate replacement by newer drugs."[1]

History

Propranolol was developed by James Black who later received the Nobel Prize for this and other work.[2]

Propranolol was marketed in the United States by Akrimax Pharms. Propranolol received approval in the United States November 13, 1967.[3]

Generic propranolol was available October 22, 1985.[4]

Metabolism

Propranolol is metabolized in the liver by several isoenzymes of cytochrome P-450.

External links

The most up-to-date information about Propranolol and other drugs can be found at the following sites.


References

  1. Anonymous (2015), Propranolol (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Stapleton MP (1997). "Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology". Tex Heart Inst J 24 (4): 336–42. PMID 9456487. PMC 325477[e]
  3. Drugs@FDA. U S Food and Drug Administration
  4. Drugs@FDA. U S Food and Drug Administration