Platelet glycoprotein GPIIb-IIIa complex

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Platelet Glycoprotein GPIIb-IIIa Complex is a "platelet membrane glycoprotein complex important for platelet adhesion and aggregation. it is an integrin complex containing integrin alphaiib and integrin beta3 which recognizes the arginine-glycine-aspartic acid (rgd) sequence present on several adhesive proteins. as such, it is a receptor for fibrinogen; von Willebrand factor; fibronectin; vitronectin; and thrombospondins."[1]

Role in medicine

A deficiency of GPIIb-IIIa is the cause of Glanzman Thrombasthenia, which causes a prolonged bleeding time.

Antibodies to GPIIb-IIIa is the cause of most cases of chronic idiopathic thrombocytopenic purpura (ITP).

Antibodies to immune complexes of GPIIb-IIIa and various drugs underlie many cases of drug-induced immune thrombocytopenia.[2]

Glycoprotein IIb/IIIa inhibitors (GPIs), such as eptifibatide and tirofiban, block the platelet glycoprotein GPIIb-IIIa complex and inhibit platelet aggregation. They arp used to treat vascular diseases.

References

  1. Anonymous. Platelet Glycoprotein GPIIb-IIIa Complex. National Library of Medicine. Retrieved on 2008-01-10.
  2. Aster RH, Bougie DW (2007). "Drug-induced immune thrombocytopenia". N. Engl. J. Med. 357 (6): 580–7. DOI:10.1056/NEJMra066469. PMID 17687133. Research Blogging.

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