Melanocyte-stimulating hormones are a group of peptides produced via the cleavage of pro-opiomelanocortin (POMC).
Inflammation α-MSH has potent anti-inflammatory effects although its precise mechanism is not fully understood, it is believed to influence vascular permeability and thus may act by decreasing it.
Cardiovascular Central application of γ- MSH (MC3R specific agonist, can induce tachycardia, while the bradychardia that occurs following electrical stimulation of the arcuate nucleus can be inhibited by the administration of SHU-9119 into the DVC. As it acts through MC4R this highlights a potential role for this receptor in mediating cardiovascular control.
Sexual Function Activation of MC4R plays a role in erectile function in males while MC3R is believed to induce lordosis in females.
<ref>tag; no text was provided for refs named
Cite error: Invalid