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MKULTRA was a Central Intelligence Agency program that used adults to explore more effective means of interrogation as part of the larger Project ARTICHOKE[1]. Although the CIA Director Richard Helms ordered the destruction of the MKULTRA files in 1973, some documents do remain available.

A noted example was a government scientist, Frank Olson, who was given lysergic acid diethylamide (LSD) without his knowledge by Dr Sidney Gottlieb of the CIA Technical Services Division, and who subsequently committed suicide. MKULTRA was discussed in the 1975 Rockefeller Commission report to the President,[2]

and in more detail by the U.S. Senate Church Committee.
  1. Jeffrey T. Richelson, ed. (January 31, 1975), CIA, Memorandum for the Record, Subject: Project ARTICHOKE, George Washington University National Security Archive Electronic Briefing Book No. 54, "Science, Technology and the CIA"
  2. , "The Testing of Behavior-Influencing Drugs on Unsuspecting Subjects Within the United States", Report to the President by the Commission on CIA Activities within the United States ("Rockefeller Commission"), June 1975, at 226-228