Hodgkin's disease

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Also called Hodgkin disease and Hodgkin's lymphoma, Hodgkin's disease is a malignant, but potentially curable, disease of the lymph nodes, spleen, and general lymphoid tissue.

Five variants are defined by the World Health Organization, grouped into two classes:[1]

  • Classical
    • nodular sclerosis
    • mixed cellularity
    • lymphocyte depleted
    • lymphocyte rich
  • nodular lymphocyte predominant Hodgkin disease (NLPHD).

Classical and NLHPD are different clinical entities.[2]

In the classical variant, giant usually multinucleate Hodgkin's and Reed-Sternberg cells, the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.


  1. Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001.
  2. Scott K Dessain, James L Spears, Athanassios Argiris (22 December 2009), "Hodgkin Disease: Overview", eMedicine