Hemolytic anemia

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In hematology, Hemolytic anemia is an "A condition of inadequate circulating red blood cells (anemia) or insufficient hemoglobin due to premature destruction of red blood cells (erythrocytes)."[1]

Classification

One classification is based on whether hemolysis occurs intravascularly or extravascularly. Another classification is whether the erythrocytes are intrinsically normal:[2]

Hemolytic anemia associated with normal red cells

Hemolytic anemia associated with abnormal red cells

Diagnosis

Hemolysis

Autoimmunity:

Microangiopathic hemolytic anemia

  • Platelet count
  • ADAMTS13 protein activity and inhibitor (von Willebrand factor-degrading protease)[13]

References

  1. Anonymous (2015), Hemolytic anemia (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Wright DE, Rosovsky RP, Platt MY (2013). "Case records of the Massachusetts General Hospital. Case 36-2013. A 38-year-old woman with anemia and thrombocytopenia.". N Engl J Med 369 (21): 2032-43. DOI:10.1056/NEJMcpc1215972. PMID 24256382. Research Blogging.
  3. Berentsen S, Tjønnfjord GE (2012). "Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia.". Blood Rev 26 (3): 107-15. DOI:10.1016/j.blre.2012.01.002. PMID 22330255. Research Blogging.
  4. Shih AW, McFarlane A, Verhovsek M (2014). "Haptoglobin testing in hemolysis: measurement and interpretation.". Am J Hematol 89 (4): 443-7. PMID 24809098[e]
  5. Rice L (1980). "Serum haptoglobin in hemolytic disease.". JAMA 244 (23): 2607-8. PMID 7431603[e]
  6. Marchand A, Galen RS, Van Lente F (1980). "The predictive value of serum haptoglobin in hemolytic disease.". JAMA 243 (19): 1909-11. PMID 7365971[e]
  7. Pirofsky B. Autoimmunization and the autoimmune hemolytic anemias. Baltimore; Williams & Wilkins: 1969:44-72
  8. Liesveld JL, Rowe JM, Lichtman MA (1987). "Variability of the erythropoietic response in autoimmune hemolytic anemia: analysis of 109 cases.". Blood 69 (3): 820-6. PMID 3814817[e]
  9. Bain BJ (2005). "Diagnosis from the blood smear.". N Engl J Med 353 (5): 498-507. DOI:10.1056/NEJMra043442. PMID 16079373. Research Blogging.
  10. Kamesaki T, Oyamada T, Omine M, Ozawa K, Kajii E (2009). "Cut-off value of red-blood-cell-bound IgG for the diagnosis of Coombs-negative autoimmune hemolytic anemia.". Am J Hematol 84 (2): 98-101. DOI:10.1002/ajh.21336. PMID 19105232. Research Blogging.
  11. Worlledge SM, Blajchman MA (1972). "The autoimmune haemolytic anaemias.". Br J Haematol 23: Suppl:61-9. PMID 4567200[e]
  12. Allgood JW, Chaplin H (1967). "Idiopathic acquired autoimmune hemolytic anemia. A review of forty-seven cases treated from 1955 through 1965.". Am J Med 43 (2): 254-73. PMID 6034957[e]
  13. Kremer Hovinga JA, Vesely SK, Terrell DR, Lämmle B, George JN (2010). "Survival and relapse in patients with thrombotic thrombocytopenic purpura.". Blood 115 (8): 1500-11; quiz 1662. DOI:10.1182/blood-2009-09-243790. PMID 20032506. Research Blogging.