Gell and Coombs classification of immune reactions

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For more information, see: Hypersensitivity.

In allergy and immunology, as well as a broader range of medical conditions, the Gell and Coombs classification of immune reactions[1] is widely used to categorized specific disorders into four useful categories. It has been improved, however, into subtypes and an additional type has been added.

Immediate hypersensitivity reaction encompasses types I-III, while Type IV is the delayed hypersensitivity reaction.


  1. Gell PGH, Coombs RRA, eds. Clinical Aspects of Immunology. 1st ed. Oxford, England: Blackwell; 1963.