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A list of key readings about Diabesity.
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Review Articles

  1. Magni P et al.(2009) Feeding behavior in mammals including humans Ann NY Acad Sci 1163:221-32. PMID 19456343

Speakman J et al.(2008) Thrifty vs Drifty Gene Theory of Obesity Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the 'drifty gene' hypothesis Int J Obesity 32:1611–7 The discussion of thrifty genes and drifty genes, on obesity and diabetes. Suggestion made that the case for Thrifty genes may not be correct, but rather a different hypothesis is proposed

Cameron N et al. (2006) Childhood Obesity Contemporary Issues p154, CRC press, Taylor and Francis Group. (Discusses how obesity relates very closely to Diabetes. Relates genetic and environmental factors and summarises the thrifty gene hypothesis.)

Marchand L (2002) The Pima Indians: Pathfinders for health, Obesity and Diabetes, Online resource: [1] NIDDK research conducted on the Pima Indians for the past 30 years has helped scientists prove that obesity is a major risk factor in the development of diabetes. One-half of adult Pima Indians have diabetes and 95% of those with diabetes are overweight. Scientists use the "thrifty gene" theory proposed in 1962 by geneticist James Neel to help explain why many Pima Indians are overweight

Neel JV (1962) Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 14:353–62. PMID 13937884. (The original paper that proposes the Thrifty genotype).

Again evidence that suggests the Thrifty genotype in Type 2 diabetes. And obesity Joffe, Barry; Paul Zimmet (1998-08-17). The thrifty genotype in type 2 diabetes Endocrine 9:139–41. doi:10.1385/ENDO:9:2:139.

Zimmet P et al. (2001) Global and societal implications of the diabetes epidemic. Nature 414:782–787

Langendonk JG et al. (2006) Decrease in visceral fat following diet-induced weight loss in upper body compared to lower body obese premenopausal women Eur J Intern Med 17:465–9

Palaniappan L et al.(2004) Predictors of the incident metabolic syndrome in adults. Diabetes Care 27:788–93

Nieves DJ et al. (2003) The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat. Diabetes 52:172–179.

Turner NC, Clapham JC (1998) Insulin resistance, impaired glucose tolerance and non-insulin dependent diabetes, pathologic mechanism and treatment: current status and therapeutic possibility. Drug Res 51:36–94

Gabriely I et al. (2002) Removal of visceral fat prevents insulin resistance and glucose intolerance of aging. Diabetes 51:2951–8

Tamara S et al. (2005) Childhood obesity and type 2 diabetes mellitus. Pediatrics 116:473-80

Garber J (2009). Restaging insulin therapy for patients with type 2 diabetes. Diabetes Obes Metab 11:1–5

Diabetes Prevention Program Research Group, Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin, N Engl J. Med 346: (2002) 393–403

Bray G. Drug Treatment of Obesity. Reviews in Endocrine & Metabolic Disorders. 2001; 2.

Lean MEJ et al. (1990) Obesity, weight loss and prognosis in type 2 diabetes Diabetic Med 7:228-33

Hartz AJ et al. (1983) Relationship of obesity to diabetes: influences of obesity level and body fat distribution. Prev Med 12:351-57

Umut Özcan et al. (2004) Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes. Science 306:457-61

Solinas G et al.(2007) JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity. Cell Metabol 6:386–97

Karasawaa H et al. (2009) A novel model of type 2 diabetes mellitus based on obesity induced by high-fat diet in BDF1 mice. Metabolism Clinical and Experimental 58:296–303

Butler A et al.(2003) β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes. Diabetes 52:102-10

Donath M et al.(2008) Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Diabetes Care 31:161-4

Yogev Y, Visser G (2009) Obesity, gestational diabetes and pregnancy outcome. Seminars in Fetal and Neonatal Medicine 14:77-84

Hattersley AT, Tooke JE (1999) The fetal insulin hypothesis: an alternative explanation of the association of low bir thweight with diabetes and vascular disease. Lancet353:1789-92

Chu SY et al.(2007) Maternal Obesity and Risk of Gestational Diabetes Mellitus. Diabetes Care 30:2070-6

Boney CM et al. (2005) Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 115


Dunger D, Ong K(2009) Diabetes in pregnancy: a vicious circle? Research Horizons Issue 8.