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N,N'-diisopropylcarbodiimide is a dehydration reagent that is used to activate carboxylic acids for coupling with either alcohols or amines to form ester or amide products. It is similar to N,N'-dicyclohexylcarbodiimide, another carbodiimide, in reactivity, but, as a liquid reagent, it is easier to handle and extract from reaction mixtures.

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