Cytochrome P-450 CYP2D6

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Crystal Structure of Human Cytochrome P450 2d6.
Crystal Structure of Human Cytochrome P450 2d6.

In biology, the cytochrome P-450 CYP2D6 is a "cytochrome P-450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as debrisoquine; adrenergic receptor antagonists; and tricyclic antidepressants. This enzyme is deficient in up to 10 percent of the Caucasian population."[1][2]

CYP2D6 may be responsible for metabolism of 25% of prescribed drugs[3] and 38% of drugs frequently cited for causing drug toxicity[4].

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References

  1. ↑ Anonymous, (2009) Cytochrome P-450 CYP2D6 (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 608902. World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/
  3. ↑ Wolf CR, Smith G (1999). Pharmacogenetics.. Br Med Bull 55 (2): 366-86. PMID 10723863.
  4. ↑ Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W (2001). Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review.. JAMA 286 (18): 2270-9. PMID 11710893.
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