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Cirrhosis

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Cirrhosis is a "liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules."[1]

Contents

Complications

Ascites

For more information, see: Ascites


Esophageal varices

Patients with a platelet count of less than 40 and a palpable spleen are more likely to have esophageal varices.[2] Varices are also more likely according to a clinical prediction rule if a patient has an increased alanine transaminase (ALT) level, reduced albumin level, and presence of spider angiomas.[3]

Hepatic encephalopathy

For more information, see: Hepatic encephalopathy


Hepatorenal syndrome

For more information, see: Hepatorenal syndrome


Spontaneous bacterial peritonitis

For more information, see: Spontaneous bacterial peritonitis


Prognosis

MELD Score

For more information, see: MELD Score

The MELD Score can help predict mortality. An online calculator is available.

References

  1. ↑ Anonymous. Liver cirrhosis. National Library of Medicine. Retrieved on 2008-01-07.
  2. ↑ Sharma SK, Aggarwal R (2007). "Prediction of large esophageal varices in patients with cirrhosis of the liver using clinical, laboratory and imaging parameters". J. Gastroenterol. Hepatol. 22 (11): 1909–15. DOI:10.1111/j.1440-1746.2006.04501.x. PMID 17914969.
  3. ↑ Berzigotti A, Gilabert R, Abraldes JG, et al (May 2008). "Noninvasive prediction of clinically significant portal hypertension and esophageal varices in patients with compensated liver cirrhosis". Am. J. Gastroenterol. 103 (5): 1159–67. DOI:10.1111/j.1572-0241.2008.01826.x. PMID 18477345.
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