From Citizendium
Jump to navigation Jump to search

Lefèvre J, Mangin JF (2010). "A reaction-diffusion model of human brain development". PLoS Comput Biol 6 (4): e1000749. DOI:10.1371/journal.pcbi.1000749. PMID 20421989. PMC PMC2858670. Research Blogging[e]

Based on modeling gyrification as a reaction-diffusion process, the authors provide a mechanism — compatible with the sulcal roots hypothesis — by which the folding process of the cerebral cortex can be explained, along with its anatomical variability and common malformations like polymicrogyria and lissencephaly.