Bronchiolitis obliterans organizing pneumonia

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Bronchiolitis obliterans organizing pneumonia (BOOP) is defined as "A disease formerly considered a form of interstitial pneumonia. Its etiology is obscure but it may be associated with toxic fumes, infection, and connective tissue disease. Clinical symptoms include cough, dyspnea and influenza-like symptoms with the development of the usual interstitial pneumonia in many cases. Obstructive symptoms are limited to smokers. There are patchy polypoid masses of intra-alveolar granulation tissue in small airway lumina and alveolar ducts. "Organizing" refers to unresolved pneumonia (in which the alveolar exudate persists and eventually undergoes fibrosis) in which fibrous tissue forms in the alveoli."[1]

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Cause/etiology

Most cases are idiopathic, but BOOP can be an adverse drug reaction, can also be post-infectious, and can be associated with rheumatologic diseases.[2] Culprit drugs include rituximab.[3][4]

Treatment

Prednisone is the first choice treatment.[2]

References

  1. National Library of Medicine. Bronchiolitis obliterans organizing pneumonia. Retrieved on 2007-10-29.
  2. 2.0 2.1 Epler GR (2001). "Bronchiolitis obliterans organizing pneumonia". Arch. Intern. Med. 161 (2): 158–64. PMID 11176728[e]
  3. Biehn SE, Kirk D, Rivera MP, Martinez AE, Khandani AH, Orlowski RZ (2006). "Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma". Hematological oncology 24 (4): 234–7. DOI:10.1002/hon.799. PMID 16948177. Research Blogging.
  4. Macartney C, Burke E, Elborn S, et al (2005). "Bronchiolitis obliterans organizing pneumonia in a patient with non-Hodgkin's lymphoma following R-CHOP and pegylated filgrastim". Leuk. Lymphoma 46 (10): 1523–6. DOI:10.1080/10428190500144615. PMID 16194900. Research Blogging.