Bisoprolol

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© Image: David E. Volk
Structure of Bisoprolol.
Bisoprolol
IUPAC name:
Synonyms:
Formula: C18H31NO4

 Uses: adrenergic beta-antagonist

 Properties:

 Hazards:

Mass (g/mol): CAS #:
266.34 66722-44-9



In medicine, bisoprolol is a "cardioselective beta-1-adrenergic blocker. It is effective in the management of hypertension and angina pectoris."[1]

Variation in the effects of bisoprolol may be due to adrenergic receptor genotypes.[2]

History

Bisoprolol fumarate was approved in 1992.[3] Generic bisoprolol was approved in 2002.[4]

Metabolism

It is not metabolized by cytochrome P-450 2D6 allele.

Dosage

For healthy adults, the starting dose is 5 mg orally per day (sometimes 2.5 mg) and the maximum dose is 10 to 20 mg orally per day.

Synoyms and Brand Names

Synonyms

  • bisoprolol fumarate
  • bisoprolol hemifumarate
  • bisoprolol fumerate

Brand Names

  • Cardicor
  • Concor
  • Condyline
  • Condylox
  • Detensiel
  • Emconcor
  • Emcor
  • Euradal
  • Isoten
  • Monocor
  • Soloc
  • Soprol
  • Zebeta


External links

The most up-to-date information about Bisoprolol and other drugs can be found at the following sites.


References

  1. Anonymous (2015), Bisoprolol (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Zaugg M, Bestmann L, Wacker J, et al (July 2007). "Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controlled, multicenter trial with 1-year follow-up". Anesthesiology 107 (1): 33–44. DOI:10.1097/01.anes.0000267530.62344.a4. PMID 17585213. Research Blogging.
  3. Drugs@FDA. U S Food and Drug Administration
  4. Drugs@FDA. U S Food and Drug Administration