BRCA1 gene

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In physiology, BRCA1 gene (BRCA-1 gene) is "a tumor suppressor gene located on human chromosome 17 at locus 17q21. Mutations of this gene are associated with the formation of familial breast and ovarian cancer. It encodes a large, nuclear protein that is a component of DNA repair pathways."[1]

Women who have BRCA1 or BRCA2 gene mutations, especially if there is a familial history of breast cancer, may be candidates for prophylactic mastectomy. [2]

References

  1. Anonymous (2015), BRCA1 gene (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Hartmann LC et al., "Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers", J Natl Cancer Inst 93 (21): 1633-1637