Aortic regurgitation (AR), also known as aortic insufficiency (AI), is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle.
A systematic review by the Rational Clinical Examination concluded that "Clinical examination by cardiologists is accurate for detecting AR, but not enough is known about the examinations of less-expert clinicians".
The role of vasodilator therapy is uncertain with conflicting studies. A randomized controlled trial found that nifedipine 20 mg twice daily "reduces or delays the need for aortic-valve replacement in asymptomatic patients with severe aortic regurgitation and normal left ventricular systolic function." However, a more recent placebo-controlled randomized controlled trial concluded that nifedipine 20 mg every 12 hours or enalapril 20 mg per day "did not reduce or delay the need for aortic-valve replacement in patients with asymptomatic severe aortic regurgitation and normal left ventricular systolic function."
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- Evangelista A, Tornos P, Sambola A, Permanyer-Miralda G, Soler-Soler J (2005). "Long-term vasodilator therapy in patients with severe aortic regurgitation". N. Engl. J. Med. 353 (13): 1342–9. DOI:10.1056/NEJMoa050666. PMID 16192479. Research Blogging.