Difference between revisions of "Blood-brain barrier"

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{{Image|Blood-brain barrier schematic.png|right|350px|Schematic drawing of [[cellular signalling|cellular regulation]] of [[extracellular]] [[glutamate]] [[concentration (chemistry)|concentrations]] ([Glu]ec) in normal [[brain]] function. Two [[neuron]]al [[cell bodies]] with [[dendrite|processes]] (white) make contact with each other through a [[synapse]] (center). [[astrocyte|Astrocytic]] (pink) processes encapsulate the synapse and cover also the [[abluminal]] side of the [[endothelium|blood vessel wall]] (right). The endothelial cells covering the [[luminal]] (blood) side of the vessel wall and the astrocytic processes make up the [[blood brain barrier]] (BBB). An [[oligodendroglia]]l cell (bluish), with its [[myelin]] encapsulating the [[axon]], and a [[microglia]]l cell (yellow) are seen. The astrocytes, with their high-affinity [[glutamate transporter]]s, are the main site for keeping [Glu]ec low. Even neurons express glutamate transporters, as do oligodendroglial cells, and endothelial cells at their abluminal side.}}
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{{Image|Blood-brain barrier schematic.png|right|350px|Schematic drawing of [[cellular signalling|cellular regulation]] of [[extracellular]] [[glutamate]] [[concentration (chemistry)|concentrations]] ([Glu]<sub>ec</sub>) in normal [[brain]] function. Two [[neuron]]al [[cell bodies]] with [[dendrite|processes]] (white) make contact with each other through a [[synapse]] (center). [[astrocyte|Astrocytic]] (pink) processes encapsulate the synapse and cover also the [[abluminal]] side of the [[endothelium|blood vessel wall]] (right). The endothelial cells covering the [[luminal]] (blood) side of the vessel wall and the astrocytic processes make up the blood brain barrier (BBB). An [[oligodendroglia]]l cell (bluish), with its [[myelin]] encapsulating the [[axon]], and a [[microglia]]l cell (yellow) are seen. The astrocytes, with their high-affinity [[glutamate transporter]]s, are the main site for keeping [Glu]<sub>ec</sub> low. Even neurons express glutamate transporters, as do oligodendroglial cells, and endothelial cells at their abluminal side.}}

Latest revision as of 14:31, 2 June 2010

Blood-brain barrier [r]: Specialized non-fenestrated tightly-joined endothelial cells with tight junctions that form a transport barrier for certain substances between the cerebral capillaries and the brain tissue. [e]

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(CC) Image: Rönnbäck and Hansson, 2004
Schematic drawing of cellular regulation of extracellular glutamate concentrations ([Glu]ec) in normal brain function. Two neuronal cell bodies with processes (white) make contact with each other through a synapse (center). Astrocytic (pink) processes encapsulate the synapse and cover also the abluminal side of the blood vessel wall (right). The endothelial cells covering the luminal (blood) side of the vessel wall and the astrocytic processes make up the blood brain barrier (BBB). An oligodendroglial cell (bluish), with its myelin encapsulating the axon, and a microglial cell (yellow) are seen. The astrocytes, with their high-affinity glutamate transporters, are the main site for keeping [Glu]ec low. Even neurons express glutamate transporters, as do oligodendroglial cells, and endothelial cells at their abluminal side.