Monobactams: Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.
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- Antibiotic : Drugs that reduce the growth or reproduction of bacteria.
- Beta-lactam : A group of several classes of antibiotic that share a common organic chemical structure, including the penicillins, cephalosporins, monobactams, carbapenems and moxolactam
- Aztreonam : A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in Gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
- Blood-brain barrier : Specialized non-fenestrated tightly-joined endothelial cells with tight junctions that form a transport barrier for certain substances between the cerebral capillaries and the brain tissue.
- Bacterial meningitis : Acute neurological meningeal inflammation caused by bacteria which, if untreated, is often fatal, or associated with significant sequelae.