Fentanyl/Related Articles
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Fentanyl: Fentanyl is a potent opioid analgesic with a rapid onset and short duration of action.In addition, it is a synthetic strong agonist at the μ-opioid receptors. It is given intravenously for anesthesia and titrated analgesia, but is also used in transdermal and transmucataneous forms for chronic pain management [e]
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Parent topics
- Opioid analgesic [r]: Synthetic narcotic that has opiate-like activities, which induces analgesia by mimicking endogenous opioids, at opioid receptors in the brain. [e]
- Opioid receptor [r]: G-protein coupled receptors located in the brain and various organs that bind opiates or opioid substances as ligands. [e]
- Opioid anesthetic [r]: A group of anesthetics, with fentanyl as the representative drug, given by intravenous infusion, which, while having the respiratory depressive effects of morphine, cause less depression to cardiac tissue than other classes of antibiotic; they can often be titrated for short procedures, developing much less respiratory depression when administered for a short time [e]
Subtopics
- Alfentanil [r]: A fentanyl derivative, less potent by weight but more efficient in its distribution in metabolism, thus potentially reducing respiratory depression and duration of effect once the administration of the drug is stopped [e]
- Carfentanil [r]: Probably first developed for veterinary use, an exceptionally potent, weight-for-weight, fentanyl derivative that may have been used, in aerosolized form possibly mixed with halothane; as an incapacitant in the Moscow theater hostage crisis; a number of deaths were associated with it because emergency medical personnel did not know its composition or treatment [e]
- Remifentanil [r]: A recently developed, ultrashort-acting derivative of fentanyl, which clears quickly after administration is stopped and allows rapid recovery, typically for short procedures [e]
- Sufentanil [r]: A derivative of fentanyl, used principally as an opioid anesthetic, which is 3 to 5 times more potent per unit weight than fentanyl, and approximately 100 times more potent than morphine [e]
- Transdermal patch [r]: Add brief definition or description
- Transmucosal drug administration [r]: Add brief definition or description
- Designer drug [r]: In legal-regulatory environments where there is a specific molecular definition of each licit and some illicit drugs, a modification of a molecule such that the result provides the desired recreational drug effect, but is not prohibited by drug regulations; it is specifically the goal to protect recreational use rather than, for example, to modify the molecule to remove undesirable side effects [e]
- Moscow theater hostage crisis [r]: Add brief definition or description