Renin

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Renin is a "highly specific (Leu-Leu) endopeptidase that generates angiotensin I from its precursor angiotensinogen, leading to a cascade of reactions which elevate blood pressure and increase sodium retention by the kidney in the renin-angiotensin system."[1]

Aliskiren is an oral direct renin inhibitor that according to a randomized controlled trial may have "renoprotective effects that are independent of its blood-pressure-lowering effect in patients with hypertension, type 2 diabetes, and nephropathy."[2]

References

  1. ↑ Anonymous, (2009) Renin (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK (June 2008). Aliskiren combined with losartan in type 2 diabetes and nephropathy. N. Engl. J. Med. 358 (23): 2433–46. DOI:10.1056/NEJMoa0708379. PMID 18525041.
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