Oseltamivir

From Citizendium, the Citizens' Compendium

oseltamivir
IUPAC name: see chemistry section Synonyms: Tamiflu® Formula: C16H28N2O4
Uses:	influenza A & B
Properties:	sialic acid homolog, neuraminidase inhibitor
Hazards:	see drug interactions
Mass (g/mol): CAS #: 312.4045 204255-11-8

Oseltamivir, or oseltamivir phosphate, marketed as Tamiflu®, is an acetamido cyclohexene that is a structural homolog of sialic acid and it is a neuraminidase inhibitor. It is used to treat influenze A and B infection and also is used prophylactically. The active form is the ester hydrolysed form, a carboxylate. Oseltamivir (like zanamivir) acts as a transition-state analogue inhibitor of influenza neuraminidase.

Chemistry

Its IUPAC chemical name is ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate and its chemical formula is C₁₆H₂₈N₂O₄, giving it a molecular mass of 312.4045 g/mol.

External links

The most up-to-date information about Oseltamivir and other drugs can be found at the following sites.

• Oseltamivir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Oseltamivir - Drug information for consumers from MedMaster (U.S. National Library of Medicine).
• Oseltamivir - Detailed information from DrugBank.