Dabigatran

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In medicine, dabigatran is an anticoagulant that is a direct thrombin inhibitor[1]

In 2009, dabigatran, a direct thrombin inhibitors, was compared to warfarin in the RE-LY randomized controlled trial.[2]

Dabigatran versus warfarin for atrial fibrillation[2]
InterventionOutcomes
Stroke or systemic embolismMajor bleeding Mortality
Dabigatran 110 mg twice daily 1.53% 2.71%†3.75%
Dabigatran 150 mg twice daily1.11%†3.11%3.64%
Warfarin 1.69%3.36% 4.13%
† p < 0.05 as compared to warfarin group

References

  1. ↑ Anonymous, (2009) Dabigatran (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ 2.0 2.1 Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A et al. (2009). Dabigatran versus Warfarin in Patients with Atrial Fibrillation.. N Engl J Med 361 (12): 1139-1151. DOI:10.1056/NEJMoa0905561. PMID 19717844.
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