Cyclic GMP

From Citizendium, the Citizens' Compendium

Jump to: navigation, search


This article is a stub and thus not approved.
Main Article
Talk
Related Articles  [?]
Bibliography  [?]
External Links  [?]
 
http://en.citizendium.org/wiki?title=Cyclic_GMP&printable=yes
This is a draft article, under development and not meant to be cited but you can help to improve it. These unapproved articles are subject to a disclaimer.
(CC) Image: David E. VolkcGMP
(CC) Image: David E. Volk
cGMP

In biochemistry, cyclic GMP is a "guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases."[1]

In signal transduction, cell surface receptors may activate second messenger systems such as adenyl cyclase-cyclic AMP and cyclic GMP which then may activate protein kinases which then affect downstream targets (see figure).[2]

References

  1. ↑ Anonymous, (2009) Cyclic GMP (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ Lodish, Harvey F. (1999). “20.1. Overview of Extracellular Signaling”, Molecular cell biology. New York: Scientific American Books. ISBN 0-7167-3136-3. 
Retrieved from "http://en.citizendium.org:8080/wiki/Cyclic_GMP"
Views
Personal tools