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In medicine, metoclopramide is a " dopamine D2 antagonist that is used as an antiemetic,"[1] often in emergency medicine.

In a randomized controlled trial that compared droperidol, metoclopramide, and prochlorperazine, droperidol was more effective but also caused more self-reported anxiety or restlessness.[2]

Metoclopramide may cause psychomotor agitation, this is not prevented by diphenhydramine.[3]


  1. Anonymous (2019), Metoclopramide (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Braude D et al. Antiemetics in the ED: a randomized controlled trial comparing 3 common agents. Am J Emerg Med. 2006 Mar;24(2):177-82. PMID 16490647
  3. Friedman BW, Bender B, Davitt M, et al (March 2009). "A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients". Ann Emerg Med 53 (3): 379–85. DOI:10.1016/j.annemergmed.2008.08.003. PMID 18814935. Research Blogging.