Eplerenone

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(CC) Image: David E. VolkEplerenone, an aldosterone receptor agonist.
(CC) Image: David E. Volk
Eplerenone, an aldosterone receptor agonist.

Eplerenone is an aldosterone receptor agonist, similar to spironolactone. Because it inhibits the negative regulatory feedback of aldosterone on renin secretion, increased plasma renin, and serum aldosterone, occur with its use. Eplerenone selectively binds to mineralocorticoid receptors relative to its binding to glucocorticoid, progesterone and androgen receptors.

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The most up-to-date information about Eplerenone and other drugs can be found at the following sites.


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