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Anti-Ro autobody, also called anti-SS-A, is associated with connective tissue disease, such as Sjogren's syndrome and systemic lupus erythematosus, and vasculitis.

Of patients without known illness, 3% will be positive for anti-Ro.[1]

Anti-R antibodies may be present three years before development of systemic lupus erythematosus.[2]

Patients with anti-Ro have more systematic illness.[2]


  1. Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA et al. (2003). "Development of autoantibodies before the clinical onset of systemic lupus erythematosus.". N Engl J Med 349 (16): 1526-33. DOI:10.1056/NEJMoa021933. PMID 14561795. Research Blogging.
  2. 2.0 2.1 Alexander EL, Arnett FC, Provost TT, Stevens MB (1983). "Sjögren's syndrome: association of anti-Ro(SS-A) antibodies with vasculitis, hematologic abnormalities, and serologic hyperreactivity.". Ann Intern Med 98 (2): 155-9. PMID 6600593[e]