Multiple chemical sensitivity: Difference between revisions
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imported>Pierre-Alain Gouanvic (New page: '''Multiple chemical sensitivities''', also known as environmental intolerances, is a poorly understood and often disputed syndrome which is described using the following criteria: * The ...) |
imported>Pierre-Alain Gouanvic No edit summary |
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* responses occur to multiple chemically unrelated substances; and | * responses occur to multiple chemically unrelated substances; and | ||
* symptoms involve multiple organ systems.<ref name="pmid10444033">{{cite journal |author= |title=Multiple chemical sensitivity: a 1999 consensus |journal=Arch. Environ. Health |volume=54 |issue=3 |pages=147–9 |year=1999 |pmid=10444033 |doi=}}</ref> | * symptoms involve multiple organ systems.<ref name="pmid10444033">{{cite journal |author= |title=Multiple chemical sensitivity: a 1999 consensus |journal=Arch. Environ. Health |volume=54 |issue=3 |pages=147–9 |year=1999 |pmid=10444033 |doi=}}</ref> | ||
==Epidemiology== | |||
''(in progress)'' | |||
==Genetic basis== | ==Genetic basis== | ||
People diagnosed using the 1999 consensus statement criteria<ref name="pmid10444033"/> have significant differences in some drug-metabolizing enzymes and other enzymes involved in detoxication.<ref name="pmid15256524">{{cite journal |author=McKeown-Eyssen G, Baines C, Cole DE, ''et al'' |title=Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR |journal=International journal of epidemiology |volume=33 |issue=5 |pages=971–8 |year=2004 |pmid=15256524 |doi=10.1093/ije/dyh251}}</ref> | People diagnosed using the 1999 consensus statement criteria<ref name="pmid10444033"/> have significant differences in some drug-metabolizing enzymes and other enzymes involved in detoxication.<ref name="pmid15256524">{{cite journal |author=McKeown-Eyssen G, Baines C, Cole DE, ''et al'' |title=Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR |journal=International journal of epidemiology |volume=33 |issue=5 |pages=971–8 |year=2004 |pmid=15256524 |doi=10.1093/ije/dyh251}}</ref> | ||
These findings, which require replication, point to an unequivocal somatic and toxic basis to multiple chemical sensitivities. | These findings, which require replication, point to an unequivocal somatic and toxic basis to multiple chemical sensitivities. | ||
==Immunological basis== | |||
In a case control study involving 417 persons (223 cases, 194 controls), lymphocyte count was found to be consistent low in victims of MCS.<ref name="pmid15347780">{{cite journal |author=Baines CJ, McKeown-Eyssen GE, Riley N, ''et al'' |title=Case-control study of multiple chemical sensitivity, comparing haematology, biochemistry, vitamins and serum volatile organic compound measures |journal=Occupational medicine (Oxford, England) |volume=54 |issue=6 |pages=408–18 |year=2004 |pmid=15347780 |doi=10.1093/occmed/kqh083 |issn=}}</ref> | |||
==References== | ==References== | ||
Revision as of 19:25, 17 November 2007
Multiple chemical sensitivities, also known as environmental intolerances, is a poorly understood and often disputed syndrome which is described using the following criteria:
- The symptoms are reproducible with repeated chemical exposure;
- the condition is chronic;
- low levels of exposure (lower than previously tolerated) result in manifestations of the syndrome;
- the symptoms improve or resolve when the incitants are removed;
- responses occur to multiple chemically unrelated substances; and
- symptoms involve multiple organ systems.[1]
Epidemiology
(in progress)
Genetic basis
People diagnosed using the 1999 consensus statement criteria[1] have significant differences in some drug-metabolizing enzymes and other enzymes involved in detoxication.[2] These findings, which require replication, point to an unequivocal somatic and toxic basis to multiple chemical sensitivities.
Immunological basis
In a case control study involving 417 persons (223 cases, 194 controls), lymphocyte count was found to be consistent low in victims of MCS.[3]
References
- ↑ 1.0 1.1 (1999) "Multiple chemical sensitivity: a 1999 consensus". Arch. Environ. Health 54 (3): 147–9. PMID 10444033. [e]
- ↑ McKeown-Eyssen G, Baines C, Cole DE, et al (2004). "Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR". International journal of epidemiology 33 (5): 971–8. DOI:10.1093/ije/dyh251. PMID 15256524. Research Blogging.
- ↑ Baines CJ, McKeown-Eyssen GE, Riley N, et al (2004). "Case-control study of multiple chemical sensitivity, comparing haematology, biochemistry, vitamins and serum volatile organic compound measures". Occupational medicine (Oxford, England) 54 (6): 408–18. DOI:10.1093/occmed/kqh083. PMID 15347780. Research Blogging.