Etoposide: Difference between revisions
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imported>Robert Badgett (New page: In oncology, '''etoposide''' is a "semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomeras...) |
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In [[oncology]], '''etoposide''' is a "semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle."<ref>{{MeSH}}</ref> | In [[oncology]], '''etoposide''' is a [[antineoplastic agent]] that is a "semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle."<ref>{{MeSH}}</ref> | ||
==External links== | ==External links== | ||
Revision as of 15:53, 8 September 2009
In oncology, etoposide is a antineoplastic agent that is a "semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle."[1]
External links
The most up-to-date information about Etoposide and other drugs can be found at the following sites.
- Etoposide - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Etoposide - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Etoposide - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Etoposide (English). Medical Subject Headings. U.S. National Library of Medicine.