Charcot-Marie-Tooth disease: Difference between revisions
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'''Charcot-Marie-Tooth disease (CMT)''' is part of a family of genetically-defined [[neurology|neurologic]] diseases characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. | |||
This condition has been divided into two subtypes, hereditary motor and sensory neuropathy ( HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. <ref>Adams et al., ''Principles of Neurology'', 6th ed, p1343</ref> | |||
The genetic abnormality is associated with the coding for [[peripheral myelin protein 22]]. It is most an autosomal dominant trait. | |||
Revision as of 13:28, 12 June 2010
Charcot-Marie-Tooth disease (CMT) is part of a family of genetically-defined neurologic diseases characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life.
This condition has been divided into two subtypes, hereditary motor and sensory neuropathy ( HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. [1]
The genetic abnormality is associated with the coding for peripheral myelin protein 22. It is most an autosomal dominant trait.
- ↑ Adams et al., Principles of Neurology, 6th ed, p1343