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...hree- to five-drug combinations were common, such as Cooper's regimen of [[cyclophosphamide]], [[methotrexate]], 5-fluorouracil, [[vincristine]] and [[prednisone]]. <r ...etastatic disease. In the mid-seventies, low-dose regimens, initially CMF (cyclophosphamide, methotrexate, and 5-fluorouracil) were introduced for adjuvant postoperati

...cits. Clinical research is ongoing with other immunosuppressants such as [[cyclophosphamide]] and [[methotrexate]].