Subclinical hypothyroidism: Difference between revisions

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imported>Robert Badgett
(Created page with "In medicine, '''subclinical hypothyroidism''' is an elevated thyrotropin (TSH) concentration can maintain a normal or near normal thyroxine (T4) concentration.<ref na...")
 
imported>Robert Badgett
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==Prognosis==
==Prognosis==
==Thyrotropin level===
==Thyrotropin level==
 
 
{| class="wikitable" align="right"
|+ Evolution of thyrotropin values over 5 years.<ref name="pmid17646608">{{cite journal|  author=Meyerovitch J, Rotman-Pikielny P, Sherf M, Battat E, Levy Y,  Surks MI| title=Serum thyrotropin measurements in the community:  five-year follow-up in a large network of primary care physicians. |  journal=Arch Intern Med | year= 2007 | volume= 167 | issue= 14 | pages=  1533-8 | pmid=17646608 | doi=10.1001/archinte.167.14.1533 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17646608  }} </ref>
! rowspan="2"| &nbsp;!!colspan="2"| Follow-up TSH value
|-
! TSH > 10!! TSH < 10
|-
| TSH > 10|| 35% || 64%
|-
| TSH 5.5 - 10|| 3% || 97%
|}
 
The thyrotropin level helps predict progression to overt hypothyroidism.<ref name="pmid17646608">{{cite journal| author=Meyerovitch J, Rotman-Pikielny P, Sherf M, Battat E, Levy Y, Surks MI| title=Serum thyrotropin measurements in the community: five-year follow-up in a large network of primary care physicians. | journal=Arch Intern Med | year= 2007 | volume= 167 | issue= 14 | pages= 1533-8 | pmid=17646608 | doi=10.1001/archinte.167.14.1533 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17646608  }} </ref>
The thyrotropin level helps predict progression to overt hypothyroidism.<ref name="pmid17646608">{{cite journal| author=Meyerovitch J, Rotman-Pikielny P, Sherf M, Battat E, Levy Y, Surks MI| title=Serum thyrotropin measurements in the community: five-year follow-up in a large network of primary care physicians. | journal=Arch Intern Med | year= 2007 | volume= 167 | issue= 14 | pages= 1533-8 | pmid=17646608 | doi=10.1001/archinte.167.14.1533 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17646608  }} </ref>



Revision as of 07:36, 19 April 2012

In medicine, subclinical hypothyroidism is an elevated thyrotropin (TSH) concentration can maintain a normal or near normal thyroxine (T4) concentration.[1][2][3]

Prognosis

Thyrotropin level

Evolution of thyrotropin values over 5 years.[4]
  Follow-up TSH value
TSH > 10 TSH < 10
TSH > 10 35% 64%
TSH 5.5 - 10 3% 97%

The thyrotropin level helps predict progression to overt hypothyroidism.[4]

Antithyroid peroxidase antibodies

Antithyroid peroxidase (also called antithyroid microsomal) antibodies my help predict progression to overt hypothyroidism.[5]

Screening

The US Preventive Services Task Force states:[1]

"t is uncertain whether treatment will improve quality of life in otherwise healthy patients who have abnormal TSH levels and normal free thyroxine levels"

References

  1. Jump up to: 1.0 1.1 Helfand M, U.S. Preventive Services Task Force (2004). "Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force.". Ann Intern Med 140 (2): 128-41. PMID 14734337[e]
  2. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH et al. (2004). "Subclinical thyroid disease: scientific review and guidelines for diagnosis and management.". JAMA 291 (2): 228-38. DOI:10.1001/jama.291.2.228. PMID 14722150. Research Blogging.
  3. Cooper DS, Biondi B (2012). "Subclinical thyroid disease.". Lancet 379 (9821): 1142-54. DOI:10.1016/S0140-6736(11)60276-6. PMID 22273398. Research Blogging.
  4. Jump up to: 4.0 4.1 Meyerovitch J, Rotman-Pikielny P, Sherf M, Battat E, Levy Y, Surks MI (2007). "Serum thyrotropin measurements in the community: five-year follow-up in a large network of primary care physicians.". Arch Intern Med 167 (14): 1533-8. DOI:10.1001/archinte.167.14.1533. PMID 17646608. Research Blogging. Cite error: Invalid <ref> tag; name "pmid17646608" defined multiple times with different content
  5. Díez JJ, Iglesias P (2004). "Spontaneous subclinical hypothyroidism in patients older than 55 years: an analysis of natural course and risk factors for the development of overt thyroid failure.". J Clin Endocrinol Metab 89 (10): 4890-7. DOI:10.1210/jc.2003-032061. PMID 15472181. Research Blogging.